标题：Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions作者：Rafiou Agoro, Kenneth E. White期刊：Nature Reviews NephrologyDOI: 10.1038/s41581-022-00665-xPDF 下载链接：https://is.gd/sLRYzB — 完 —关注我，记得标星哦～
Fibroblast growth factor (FGF)-23 is probably the most important regulator of serum phosphate and calcitriol (1,25(OH)2D3) levels. It is secreted by osteocytes and osteoblasts in response to oral phosphate loading or increased serum 1,25(OH)2D3 levels. In human chronic kidney disease (CKD...
Fukumoto S . FGF23-related hypophosphatemic rickets/osteomalacia: diagnosis and new treatment[J]. Journal of Molecular Endocrinology. 2020, 66(2). 版 权 声 明 版权属罕见病新进展所有,欢迎个人转发分享,其他任何媒体、网站如需转载或引用本...
第一步是检查血清磷酸盐水平降低是否是由于肾小管对磷酸盐的重吸收(TRP/ tubular reabsorption of phosphate)减少所致。 排除甲状旁腺激素(PTH)驱动的肾小管磷酸盐重吸收减少后,应检查肾性磷酸盐消耗的其他两个主要原因:固有肾磷酸盐转运缺陷和成纤维细胞生长因子23 (FGF23)相关原因,如X连锁低磷酸盐血症(XLH)1。
FGF23 is a hormone involved in the regulation of phosphate metabolism and vitamin D metabolism. Klotho protein is a transmembrane protein that can regulate the activity of FGF23. Studies have shown that FGF23 and Klotho proteins are related to cardiovascular disease. However, the relationship ...
functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq...
肾性磷酸盐消耗综合征(Renal phosphate wasting syndromes)由一组异质性疾病组成,具有多种病因,在生化上表现为低磷酸盐血症。低磷血症的鉴别诊断有很多: 第一步是检查血清磷酸盐水平降低是否是由于肾小管对磷酸盐的重吸收(TRP/ tubular...
Purpose To characterize the relationship between the cFGF23/Klotho ratio and phosphate level in patients with chronic kidney disease (CKD).doi:10.1007/s11255-019-02079-4Liu, ZhongyanZhou, HaoChen, XiaoyingChen, HongWang, YiWang, TingCai, Luyan...
typel i tter-m ates.Resul ts:Com paredw i th thew i l d—type l i tterm ates,serumphosphatel evel of FG F一23transgeni cm i ce w as de—creasedsi gni fi cantl y(P<0.001);SO Dand G SH —PXacti vi 哆w erereducedsi gni fi cantl y( P<0.001) ,M DAcontentw as i n...
CKD －MBD 是指慢性肾脏病矿物质及骨代谢紊乱（chronic kidney disease －mineral and bone disorder ），本病患者多有骨痛，甚至自发性骨折，严重影响患者的生活质量和生存时间。矿物质和骨代谢紊乱是CKD 患者的常见并发症，CKD 患者在早期就已经发生矿物质代谢平衡的破坏，CKD －MBD 的发生与继发性甲状旁腺功能亢进...