Effect of phosphate binders on serum FGF-23 levels in maintenance hemodialysis patients with hyperphosphatemia目的:近年来,许多研究显示高水平的FGF-23与肾脏疾病进展,心血管病死率及左心室肥厚相关.饮食磷限制及磷结合剂可用来控制磷酸盐平衡及升高的血清FGF-23水平.本研究的目的在于比较碳酸镧和碳酸钙对于维持...
低磷血症的鉴别诊断有很多: 第一步是检查血清磷酸盐水平降低是否是由于肾小管对磷酸盐的重吸收(TRP/ tubular reabsorption of phosphate)减少所致。 排除甲状旁腺激素(PTH)驱动的肾小管磷酸盐重吸收减少后,应检查肾性磷酸盐消耗的其他两个主要原因:固有肾磷酸盐转运缺陷和成纤维细胞生长因子23 (FGF23)相关原因,如...
低磷血症的鉴别诊断有很多: 第一步是检查血清磷酸盐水平降低是否是由于肾小管对磷酸盐的重吸收(TRP/ tubular reabsorption of phosphate)减少所致。 排除甲状旁腺激素(PTH)驱动的肾小管磷酸盐重吸收减少后,应检查肾性磷酸盐消耗的其他...
Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats Kidney Int, 69 (2006), pp. 531-537 View PDFView articleCrossrefView in ScopusGoogle Scholar 23. A.A. Portale, B.E. Booth, B.P. Halloran, et al. Effect of dietary phosphorus...
Markedly high FGF23 may also exert a toxic effect on the cardiovascular system. Furthermore, down-regulation of Klotho occurs systemically (transmembrane form in the kidney, parathyroid and bone; and soluble form in the circulation) in renal failure, which may further complicate the pathogenesis of...
△通讯作者 CKD －MBD 是指慢性肾脏病矿物质及骨代谢紊乱（chronic kidney disease －mineral and bone disorder ），本病患者多有骨痛，甚至自发性骨折，严重影响患者的生活质量和生存时间。矿物质和骨代谢紊乱是CKD 患者的常见并发症，CKD 患者在早期就已经发生矿物质代谢平衡的破坏，CKD －MBD 的发生与继发性甲状...
not remain significantly associated with severe AKI after adjustment for illness severity in the present study, suggesting that the positive correlation of age with AKI might be due to the higher prevalence of severe underlying diseases in older children, rather than due to a direct effect of age...
The aim of this study was to explore whether the C-terminal of FGF23 (FGF23C-tail), an antagonist that can block the FGF23 signaling pathway by competing with intact FGF23, could exhibit a therapeutic effect on DN. Biochemical data and histological examination showed that FGF23 C-tail ...
In this setting, FGF23 may exert a toxic effect on the cardiovascular system in a Klotho-independent manner. Future research should examine whether treatment to attenuate the pathogenic action of FGF23 provides survival benefits in patients with CKD. 展开 ...
Introduction and Aims: Klotho is a protein that has anti-aging properties and is known to function as an obligate co-receptor of FGF23 in the regulation of phosphate homeostasis and also to be involved in insulin/IGF1 and WNT signaling, ... K Tsuchiya,S Shiohira,H Sugiura,... - 《Neph...