标题：Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions作者：Rafiou Agoro, Kenneth E. White期刊：Nature Reviews NephrologyDOI: 10.1038/s41581-022-00665-xPDF 下载链接：https://is.gd/sLRYzB — 完 —关注我，记得标星哦～
Heritable disorders of hyperphosphatemia and elevated 1,25(OH)2D, such as tumoral calcinosis (TC), are associated with reduced FGF23 activity. These collective findings have provided unique insight into the activity of FGF23 on renal Pi and vitamin D metabolism.doi:10.1002/9781119266594.ch25...
FGF23 is a hormone involved in the regulation of phosphate metabolism and vitamin D metabolism. Klotho protein is a transmembrane protein that can regulate the activity of FGF23. Studies have shown that FGF23 and Klotho proteins are related to cardiovascular disease. However, the relationship ...
第一步是检查血清磷酸盐水平降低是否是由于肾小管对磷酸盐的重吸收(TRP/ tubular reabsorption of phosphate)减少所致。 排除甲状旁腺激素(PTH)驱动的肾小管磷酸盐重吸收减少后,应检查肾性磷酸盐消耗的其他两个主要原因:固有肾磷酸盐转运缺陷和成纤维细胞生长因子23 (FGF23)相关原因,如X连锁低磷酸盐血症(XLH)1。
第一步是检查血清磷酸盐水平降低是否是由于肾小管对磷酸盐的重吸收(TRP/ tubular reabsorption of phosphate)减少所致。 排除甲状旁腺激素(PTH)驱动的肾小管磷酸盐重吸收减少后,应检查肾性磷酸盐消耗的其他两个主要原因:固有肾磷酸盐...
Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia. 包装清单: 产品...
and invasion. FGF-23 regulates homeostasis of phosphate and vitamin-D metabolism. FGF-23 inhibits renal tubular phosphate transport by reducing SLC34A1 levels, and negatively regulates osteoblast differentiation and matrix mineralization. FGF-23 also upregulates EGR1 expression in the presence of KL, ...
This article reviews the role of fibroblast growth factor 23 (FGF23) protein in phosphate metabolism, highlighting its regulation of vitamin D, parathyroid hormone, and bone metabolism. Although it was traditionally thought that phosphate鈥揷alcium homeostasis was controlled exclusively...
Role of the vitamin D receptor in FGF23 action on phosphate metabolism FGF23 (fibroblast growth factor 23) is a novel phosphaturic factor that influences vitamin D metabolism and renal re-absorption of Pi. The goal of the pres... Y Inoue,H Segawa,I Kaneko,... - 《Biochemical Journal》 ...
FGF23 plays a central role in phosphorus metabolism. This role was initially delineated by the study of genetic and acquired conditions of hypophosphatemic rickets but the greatest clinical impact of the discovery of FGF23 may be in the management of CKD patients. In patients with CKD, FGF23 ...