参考资料：标题：Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions作者：Rafiou Agoro, Kenneth E. White期刊：Nature Reviews NephrologyDOI: 10.1038/s41581-022-00665-xPDF 下载链接：https://is.gd/sLRYzB — 完 —关注我，记得标星哦～
参考文献: Fukumoto S . FGF23-related hypophosphatemic rickets/osteomalacia: diagnosis and new treatment[J]. Journal of Molecular Endocrinology. 2020, 66(2). 版 权 声 明 版权属罕见病新进展所有,欢迎个人转发分享,其他任何媒体、网站如需...
Fibroblast growth factor (FGF)-23 is probably the most important regulator of serum phosphate and calcitriol (1,25(OH)2D3) levels. It is secreted by osteocytes and osteoblasts in response to oral phosphate loading or increased serum 1,25(OH)2D3 levels. In human chronic kidney disease (CKD...
2020年2月Eugene P. Rhee教授团队在《The Journal of Clinical Investigation》杂志上发表了题为“Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney”的文章,为“肾-骨”轴理论又增添了新的观点:...
肾性磷酸盐消耗综合征(Renal phosphate wasting syndromes)由一组异质性疾病组成,具有多种病因,在生化上表现为低磷酸盐血症。低磷血症的鉴别诊断有很多: 第一步是检查血清磷酸盐水平降低是否是由于肾小管对磷酸盐的重吸收(TRP/ tubular reabsorption of phosphate)减少所致。
and invasion. FGF-23 regulates homeostasis of phosphate and vitamin-D metabolism. FGF-23 inhibits renal tubular phosphate transport by reducing SLC34A1 levels, and negatively regulates osteoblast differentiation and matrix mineralization. FGF-23 also upregulates EGR1 expression in the presence of KL, ...
基因:由磷酸盐调节内肽酶同源物X连锁(phosphate-regulating endopeptidasehomolog X-linked,PHEX)基因突变引起; 机制:PHEX基因在骨细胞中表达,其失活导致FGF-23浓度升高,机制尚不清楚; 通常出现在儿童时期,但较轻症疾病可能直到成年后才被发现; 这种类型的低磷血症与更常见的维生素D缺乏相比,碱性磷酸酶的升高相对较小...
內科學誌 2012: 23: 199-205FGF-23在慢性腎衰竭導致之 續發性副甲狀腺機能亢進中所扮演的角色江銘彥 黃志強 呂宜樺 吳佳純 簡志強 甘偉志 王憲奕 鄭高珍1奇美醫療財團法人奇美醫院 1內科部 內科部腎臟科摘 要慢性腎臟病 患 者由 於磷酸鹽 (phosphate)堆積、 血鈣 (calcium)下降、 以 及活性維生素D3(...
PBS(phosphate buffered solution)即磷酸盐缓冲液,能够提供相对稳定的离子环境和pH缓冲能力,是生物学中经常使用的缓冲盐溶液,用于分子克隆及细胞培养等,pH为7.2-7.4,与人体血液等渗,主要成分为磷酸二氢钾、磷酸氢二钠、氯化钠以。 二、柠檬酸钠抗原修复液: ...
FGF23 is a hormone involved in the regulation of phosphate metabolism and vitamin D metabolism. Klotho protein is a transmembrane protein that can regulate the activity of FGF23. Studies have shown that FGF23 and Klotho proteins are related to cardiovascular disease. However, the relationship ...