Adult neurogenesis, the generation of new neurons from neural stem cells (NSCs), occurs throughout life in two regions of the adult mammalian brain: the subependyma (SE), which lines the lateral ventricles in the forebrain and the subgranular zone of the dentate gyrus in the hippocampus. In...
造血干细胞(hematopoietic stem cells)的基因突变会导致细胞遗传学异常引发骨髓恶性肿瘤,包括骨髓增生异常综合征(MDS)和急性髓系白血病(AML)【1】。该过程中的一个常见现象是细胞核形态发育不良,即在显微镜下细胞的外观与正常情况不同【2】...
In this Review, we discuss how different translation mechanisms control the function of adult and embryonic stem cells. Stem cells are characterized by low global translation rates despite high levels of ribosome biogenesis. The maintenance of pluripotency, the commitment to a specific cell fate and ...
2 Okada, S.et al.In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells.Blood80, 3044-3050 (1992). 3 Cabezas-Wallscheid, N.et al.Vitamin A-Retinoic Acid Signaling Regul...
We have seen above that there are intriguing similarities in the way stem cells function in both plants and animals to sustain growth and replace tissues. To perform their functions, stem cells are different from other cells in two ways. First, they are able to produce copies of themselves ov...
在机体处于损伤、感染以及自身免疫激活状态时,成熟的血细胞既是炎性因子的主要来源,也是炎症反应所必须的下游响应因素。当然,有证据表明,不成熟的造血干细胞和前体细胞也是炎症反应中重要的一环【1,2】。事实上,多种不同类型的炎症刺激均可以激活造血干细胞,使其由静息状态进入活化增殖状态【3】。通常意义来说,“休...
Stem Cells:女性经血可修复心脏 日本科学家在最新一期美国《干细胞》期刊发表研究报告,表示可利用经血培植心肌细胞,修复心脏损伤,且成功率比采用骨髓干细胞的0.2%至0.3%高达百倍。 研究由庆应大学及国立成育医疗中心联合进行,科学家将9名女子经血中的间叶细胞培植增生1个月后,将之与老鼠心脏细胞混和,发现三天后其中...
近日,来自美国斯坦福大学的Thomas A. Rando团队在Cell Stem Cell上在线发表题为Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells的文章,发现了一个控制FAP向脂肪细胞分化的分子命运开关——miR-206:Runx1轴,miR-206在激活的FAP中的表达增加,可以以...
This postdoctoral fellow position will focus on studying the mechanisms by which ubiquitin-dependent signaling and ribosome biogenesis in regulating stem cells and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. ...
cells. Stem cells then divide and start to proliferate, and daughter cells differentiate into the different epithelial cells. In the case of damage to, or loss of, the CBCs, the +4 LRCs substitute the lost stem cell function and create new crypts with all cells present, including new Lgr...