Mouse embryonic stem cells have been differentiated into mature stomach tissue by inducing mesenchymal Barx1 , a gene that drives stomach development in cells from the gut endoderm. In 3D cultures, Barx1 induction led to the generation of spheroids that develop into mature stomach tissue, modelling...
“The stomach makes its own hormone-secreting cells, and stomach cells and pancreatic cells are adjacent in the embryonic stage of development, so in that sense it isn’t completely surprising that gastric stem cells can be so readily transformed into beta-like insulin-secreting cells,” said Jo...
4f,g). To understand whether the shift in regional identity in crypt cells translates to the villi and results in altered function, we performed scRNA-seq of villus cells from the SI (Extended Data Fig. 5a–c). We focused on enterocytes because regional and spatial compartmentalization of ...
Stem cells reside within instructive niches that dictate their function; candidate ovary niche sources encompass the mature epithelial progeny and underlying follicular and stromal cells. Epithelial ovarian cancers, which form the majority of ovarian cancers in humans, are believed to originate from the ...
Stomach epithelial stem cellsMills, Jason CShivdasani, Ramesh A
It seems plausible that with each cell division, the potential of a HSC to contribute to blood cell production declines and that, simultaneously, the pool of stem cells with reduced potential increases to compensate for loss of function of individual stem cells (Figure 1). Figure 1. ...
Human stem cells harbor significant potential for basic and clinical translational research as well as regenerative medicine. Currently ~ 3000 adult and ~ 30 pluripotent stem cell-based, interventional clinical trials are ongoing worldwide, and num
stem cellswould result in novelanticancertherapies directed against cancer stem cells. The field of cell therapy and that of anticancer therapy are inextricably linked; understanding the biology of liver stem cells will benefit both fields greatly. This chapter is limited to liver-derived stem cells....
The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic application, have aroused considerable interest and expectations. With self-renewal capabilities and grea
The new science behind stem cells is treating incurable diseases, but there's also been fraud and false hope around this miracle medicine.