1. Joana Figueiredo, Soraia Melo, Patrícia Carneiro1, et al: Clinical spectrum and pleiotropic nature of CDH1 germline mutations. Journal of medical genetics: eJMG. ,2019 2. Wenyi Luo, Faysal Fedda, Patrick Lynch, et al. CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and...
CDH1 gene mutation in early-onset, colorectal signet-ring cell carcinoma - ScienceDirectAlan Aitchison aChristopher Hakkaart bMartin Whitehead cSadaf Khan dSabeehuddin Siddique dRashida Ahmed dFrank A. Frizelle aJacqueline I. Keenan aPathology - Research and Practice...
20192. Wenyi Luo, Faysal Fedda, Patrick Lynch, et al. CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis and Treatment. Front Pharmacol.
1. Joana Figueiredo, Soraia Melo, Patrícia Carneiro1, et al: Clinical spectrum and pleiotropic nature of CDH1 germline mutations. Journal of medical genetics: eJMG. ,2019 2. Wenyi Luo, Faysal Fedda, Patrick Lynch, et al. CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and...
This is an autosomal dominant syndrome characterized by the development of diffuse (signet ring cell) gastric cancers at a young age.Truncating mutations in CDH1, the gene encoding the cell adhesion molecular E-cadherin, are found in 30% to 50% of cases. The lifetime risk for gastric cancer...
【Key words】 Familial cancer syndrome;CDH1 gene;Germline mutation, Gastric cancer/Breast cancer 临床研究发现, 部分肿瘤发病有家族史, 即同一家系中肿瘤发病率很高 ,且发病年龄较轻。肿瘤的发生部位可以不局限于同一组织或器官 。此种家族发病有呈常染色体显性遗传特点, 以往称之为“癌家族” ,最近文献将其称...
The human CDH1 gene is shown in the context of the human genome below. To see information about the CDH1 gene in other species, please use theSearch Toolto select your desired species. GenScript has in-stock ORF clones for mouse CDH1, rat CDH1, and human CDH1, as well as on-demand CD...
Indeed, they code for E-cadherin and Catenin delta 1 (p120CTN) respectively, two interacting intercellular adhesion proteins that have, among others, a key role in craniofacial development.5,6 In addition, CDH1 is an established susceptibility gene for nonsyndromic CLP, with, for example, 4/81...
CDH1基因介绍.docx,CDH1基因突变诊断研究进展 摘要: E-钙黏蛋白(cadherin)基因(CDH1基因)外显子突变是目前已知的、导致HDGC等多种肿瘤发病的最重要因素, 筛查其突变情况可以用于指导肿瘤的临床诊治,CDH1基因的其他改变, 如内含子突变、基因甲基化及单核苷酸多态性也可能
CDH1 (cadherin 1) 该基因编码E-钙粘蛋白(E-Cadherin)是钙依赖性细胞粘附蛋白,属于钙粘蛋白家族成员,CDH1基因参与调节细胞粘附、迁移和上皮细胞增殖,其功能缺失导致细胞更容易侵袭与转移,该基因的突变与胃癌、乳腺癌、结直肠癌、甲状腺癌和卵巢癌密切相关。