Signs and symptoms of the disease often only occur when advanced or metastatic disease is present. A very small number of gastric cancers are hereditary. The mutation to the E-cadherin gene has high penetrance and confers a lifetime risk of gastric cancer of 80% for carriers. Because of the...
This is probably due to the lack of proper screening programs and a lack of symptoms for a long time. About 35% of patients present with “de novo” metastatic GC (mGC) and approximately 70% that underwent surgery for the primary tumor will have disease recurrence or develop distant ...