Multiparametric MRI-based differentiation of WHO grade II/III glioma and WHO grade IV glioblastoma. Sci Rep 2016;6:35142.Wiestler B, Kluge A, Lukas M, Gempt J, Ringel F, Schlegel J, et al. Multiparametric MRI-based differentiation of WHO grade II/III glioma and WHO grade IV glioblastoma...
(mutations, amplifications, gene fusions) of the elements of pathways typically affected in glioblastoma (PI3K/RAS,TP53,and RB pathways). The prognosis of diffuse midline gliomas is dismal, with 2-year overall survival rate below 10% despite therapy. Histone mutations are associated with a ...
Gliomas are the most common tumor type in the central nervous system (CNS) and range from slowly growing low-grade tumors to rapidly growing high-grade tumors, such as anaplastic astrocytoma and glioblastoma (GBM). The majority of gliomas are malignant and the high mortality rate of patients co...
Diffusion MRI is an early biomarker of overall survival benefit in IDH wild-type recurrent glioblastoma treated with immune checkpoint inhibitors. Neuro Oncol. 2022;24(6):1020-1028. Wang S, O’Rourke DM, Chawla S, Verma G, Nasrallah MP, Morrissette JJD, Plesa G, June CH, Brem S, Maloney...
unprocessed surgical specimens from both IDH-wild-type glioblastomas and IDH-mutant diffuse gliomas. FastGlioma outperforms standard-of-care image-guided and fluorescence-guided intraoperative methods for tumour-infiltration detection by a substantial margin. FastGlioma can be generalized to other paediatric...
diffuse astrocytoma,IDH-wildtype. The latter raising concern for molecular glioblastoma (GBM). Both of these diagnoses may lead to conventional adult diffuse glioma treatments involving cytotoxic chemotherapy and radiation, particularly in the adolescent and young adult age group. However, inIDH1wild-typ...
New prognostic factor telomerase reverse transcriptase promotor mutation presents without MR imaging biomarkers in primary glioblastoma. Neuroradiology. 2017;59(12):1223–31. 40. Zhou H, Vallieres M, Bai HX, Su C, Tang H, Oldridge D, Zhang Z, Xiao B, Liao W, Tao Y, et al. MRI features...
Role of chromosomal aberrations in the progression of glioblastoma—IDH wildtype. glioblastoma multiforme, GBM; isocitrate dehydrogenase, IDH; epidermal growth factor receptor, EGFR; tumor protein p53, TP53; phosphatase and tensin homolog, PTEN; cyclin-dependent kinase inhibitor 2A, CDKN2A; retinoblastoma...
glioblastomas developed an ischemic stroke on the tumor site.17,18A recent case study reported that the risk of neurodegeneration and ischemic lesions increases after resection of recurrent tumors.19The case of an anaplastic astrocytoma patient showed acute onset ischemic stroke-like symptoms.20In ...
A group of patients with newly diagnosed glioma was recruited from ZNH (4 diffuse astrocytomas, IDH mutant; 2 oligodendroglioma, IDH mutant and 1p/19q codeleted; 5 glioblastoma IDH wildtype). Based on conventional imaging findings in these MRI scans, two to six sphere targets of 5 mm in...