(OH)2D3-mediated cell death in glioma cells is dependent on protein synthesis and upregulation of c-myc expression, IL-6, vaso-endothelial growth factor and gadd45 gene expression[117]. In glioblastoma multiforme cell lines that were resistant to 1,25(OH)2D3, resistance cannot be overcome ...
69 For example, suppression of BCAT1, an amino acid transferase involved in catabolism of branch-chain amino acids and mutated in glioma in a mutually exclusive fashion with IDH1 and IDH2, resulted in reduced invasiveness and proliferation in vitro and in a glioblastoma multiforme xenograft model....
gliomas can be categorized into four grades (grade I to IV), among which grade IV is also called glioblastoma or glioblastoma multiforme (GBM) [3]. Moreover, a gene expression-based molecular classification of glioblstoma has been presented, including proneural, neural, classical...
Introduction Glioblastoma multiforme (GBM) is the most common primary malignant tumor of the central nervous system and is resistant to conventional therapies, including surgery, radiotherapy and chemotherapy [1,2]. The median survival time of GBM patients receiving standard-of-care treatment is approxi...
An integrated genomic analysis of human glioblastoma multiforme. Science. 2008;321(5897):1807–12. https://doi.org/10.1126/science.1164382. Article CAS PubMed PubMed Central Google Scholar Huang J, Yu J, Tu L, Huang N, Li H, Luo Y. Isocitrate dehydrogenase mutations in glioma: from ...
Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker J. Neurosurg., 93 (2000), pp. 618-625 Google Scholar [41] D.M. Feldser, C.W. Greider Short telomeres limit tumor progression in vivo by inducing senescence Cancer Cell, 11 (2007), pp...
The Adult Malignant Glioma Therapeutics Market is Segmented by Type of Disease (Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Anaplastic Oligoastrocytoma, and Other Types of Diseases), Therapy (Chemotherapy, Targeted Drug Therapy, and Radiation Therapy) and Geography (North ...
The RNA sequencing data in transcripts per kilobase million (TPM) format for TCGA-LGG (Lower Grade Glioma; WHO grade II–III) and TCGA-GBM (glioblastoma multiforme; WHO grade IV) were uniformly processed by TOIL and downloaded from UCSC Xena (https://xenabrowser.net/datapage/). ...
Inflammatory cytokines, interleukin-1 beta and tumor necrosis factor-alpha, upregulated in glioblastoma multiforme, raise the levels of CRYAB in exosomes secreted by U373 glioma cells Biochem Biophys Res Commun, 453 (3) (2014), pp. 326-331 View PDFView articleView in ScopusGoogle Scholar ...
onset ischemic stroke-like symptoms.20In another interesting case, a 79-year-old woman with a history of atrial fibrillation and coronary heart disease developed glioblastoma multiforme (GBM) at the site of a previous infarction 6 years after the onset of right hemiplegia.21Cerebral ischemia might...