died of liver related causes.ResultsAmong DILIN's 10 amiodarone and 3 dronedarone DILIN cases, the latency for amiodarone was longer than with dronedarone (388 vs 119 days, p = 0.50) and the median ALT at DILI onset was significantly lower with amiodarone (118 vs 1191 U/L, p = 0.05)...
No significant difference was observed in the sinus rhythm maintenance rate between the D-R group and the A-R group (26.8% vs. 22.0%, P =0.43).Compared to co-administration of amiodarone and rivaroxaban, co-administration of dronedarone and rivaroxaban increases the risk of CRNMB but it ...
Amiodarone is an effective treatment for atrial and ventricular arrhythmias, but its use is limited by a toxic adverse-effect profile. Although dronedarone... JE Gonzalez,WH Sauer,MJ Krantz - 《Pharmacotherapy》 被引量: 6发表: 2013年 use of dronedarone for the preparation of a drug for the ...
However, the risk of proarrhythmia, only modest efficacy, and the risk of organ toxicity (amiodarone) have complicated antiarrhythmic drug therapy. In a recent meta-analysis ( 6 ), Vaughan-Williams Class 1A antiarrhythmic agents like quinidine and disopyramide were associated with a > 2-fold ...
dronedaroneBACKGROUND Dronedarone is a benzofuran-derived antiarrhythmic agent with a similar pharmacologic profile to that of amiodarone. OBJECTIVE To assess the efficacy of dronedarone for the maintenance of sinus rhythm in patients with cardioverted, recurrent atrial fibrillation (AF). DESIGN This was...
Amiodarone-induced changes were much more pronounced than those of dronedarone on (1) action potential duration (ΔAPD 90, +51 ± 17 ms vs. 4 ± 6 ms, P >.01), (2) effective refractory period (ΔERP, +84 ± 23 ms vs. 18 ± 9 ms, P <.001), (3) diastolic threshold of ...
AF recurrence after successful cardioversion was 36.5 and 24.3% with dronedarone and amiodarone, respectively. Premature drug discontinuation tended to be less frequent with dronedarone (10.4 vs 13.3%). MSE was 39.3 and 44.5% with dronedarone and amiodarone, respectively, at 12 months...
Introduction: Dronedarone was introduced as a promising Amiodarone-analogue with a good safety profile and comparing efficacy. Because of a two-fold increase in all-cause death, stroke, myocardial infarction, and hospitalization in permanent AF, recommendations regarding the use of dronedarone therapy ...
For IS, the incidence rate was 1.68 per 100 person-year in amiodarone vs. 0.84 in dronedarone but results did not reach statistical significance (IRR=1.91, 95% CI: 0.84-4.30, p=0.12); for TIA, it was 3.67 vs. 2.35 for amiodarone and dronedarone respectively (IRR=2.01...
No significant difference was observed in the sinus rhythm maintenance rate between the D-R group and the A-R group (26.8% vs. 22.0%, P =0.43).Compared to co-administration of amiodarone and rivaroxaban, co-administration of dronedarone and rivaroxaban increases the risk of CRNMB but it ...