Krishnan, Zonisamide for weight loss in obese adults: a randomized controlled trial. JAMA 289 , 1820–1825 (2003)Gadde et al. , " Zonisamide for Weight Loss in Obese Adults-A Randomized Controlled Trial " JAMA 289 (14): 1820-1825 (2003)....
Bupropion/zonisamide is effective for weight loss in obese patients
Zonisamide for weight loss in obese adults: a randomized controlled trial. JAMA 2003; 289: 1820–5. 2. Gadde KM, et al. Combination therapy of zonisamide and bupro- pion for weight reduction in obese women: a preliminary, rand- omized, open-label study. J Clin Psychiatry 2007; 68: ...
Other: abnormal taste, weight loss, allergic reactions, oligohidrosis and hyperthermia (in children), flulike symptoms, accidental injury Interactions Drug-drug. Carbamazepine, phenobarbital, phenytoin, valproic acid: decreased zonisamide blood level and effects CYP450-3A4 inducers: decreased zonisamide ...
Patients should contact their clinician immediately if they develop symptoms of metabolic acidosis such as fast breathing (hyperventilation), fatigue, loss of appetite, irregular heart beat, palpitations, or unconsciousness. Potential for drowsiness, especially at higher dosages. Importance of advising pati...
There is preliminary evidence for possible usefulness of zonisamide in the treatment of obesity and psychotropicassociated weight gain, as well as alcohol dependence and withdrawal. References https://en.wikipedia.org/wiki/Zonisamide http://www.medicinenet.com/zonisamide-oral/article.htm https://pub...
The most common adverse reactions leading to discontinuation were somnolence, fatigue and/or ataxia (6%), anorexia (3%), difficulty concentrating (2%), difficulty with memory, mental slowing, nausea/vomiting (2%), and weight loss (1%). Many of these adverse reactions were dose-related (see ...
Zonisamide for Weight Loss in Obese Adults: A Randomized Controlled Trial. Weight loss was an adverse effect associated with zonisamide treatment in epilepsy clinical trials. Objective: To evaluate the efficacy of zonisamide for ... Gadde,M Kishore,Franciscy,... - 《Jama Journal of the American...
There is a need for a method to treat an overweight and/or obese subject such that the weight loss is significant and sustained over time. There is also a need for a method to treat eating disorders such as binge-eating disorders, bulimia nervosa and anorexia nervosa. ...
Zonisamide for Weight Reduction in Obese Adults: A 1-Year Randomized Controlled Trial BACKGROUND: Obese individuals who have failed to achieve adequate weight loss with lifestyle changes have limited nonsurgical therapeutic options. We evalu... KM Gadde,MF Kopping,WH Nd,... - 《Archives of Inte...