Dogs on phenobarbital will need monitoring of liver values, and if indications of hepatic damage occur, may be switched to a newer anti-seizure medication such as Keppra or zonisamide. Save the Liver! This important organ plays a central role in all metabolic processes in the body, detoxifies...
AIM: To evaluate the efficacy of zonisamide as a monotherapy in dogs with idiopathic epileptic seizure. METHODS: The experiment was conducted on 10 dogs with idiopathic epilepsy that were treated at the Seoul National University Hospital for Animals. A diagnosis was conducted based on physical and ...
The low effect dose for malformations produced peak maternal plasma zonisamide levels (25 mcg/mL) about 0.5 times the highest plasma levels measured in patients receiving the maximum recommended human dose (MRHD) of 400 mg/day. In dogs, cardiovascular malformations were found in approximately 50%...
Veterinary Drugs and Treatments Zonisamide may be useful as an “add-on” drug for refractory epilepsy in dogs. Drug interactions Potentially hazardous interactions with other drugs Antidepressants: anticonvulsant effect antagonised; avoid with St John’s wort. Antimalarials: anticonvulsant effect antag...
8.Primary study of nimotuzumab combined with radiotherapy and concomitant temozolomide chemotherapy treatment for high-grade glioma尼妥珠单抗联合放疗加同期替莫唑胺治疗高分级胶质瘤的初步研究 9.Appliation of Remifentanil Combined Midazolam,Ketamine and Propofol in Total Intraverous Anesthesia of Children瑞芬太...
Zonisamide (Zonegran®, Excegran®) is a new-generation, broad-spectrum antiepileptic drug (AED) currently approved as adjunctive therapy for the treatment of medically refractory partial seizures in adults in the US and as adjunctive therapy or monotherapy in the control of partial and generalise...
(Vd) of zonisamide at steady-state, Vd values were reduced from 1.8 L/kg after a single 200mg dose to 1.2 L/kg after an 800mg dose in studies which recruited volunteers in the US, reflecting nonlinear binding to erythrocytes. For the purpose of therapeutic monitoring, it is recommended ...
early body weight losses occurred in dogs given 75 mg/kg/day. Morris (Epilepsia41: 39 (2000)) discloses that weight loss was an adverse event for patients treated with anti-epilepsy drugs zonisamide, however, the weight loss did not continue over...
dogspharmacokineticsblood plasmaerythrocytesveterinary drugsblood1,2-benzisoxazole-3-methanesulfon-amide (Zonisamide) is an antiepileptic drug which has been approved in Japan, the United States, and Europe for administration to humans. Extensive clinical experience in humans revealed that it exhibits a ...
Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs[J] . K.ORITO,M.SAITO,K.FUKUNAGA,E.MATSUO,S.TAKIKAWA,M.MUTO,K.MISHIMA,N.EGASHIRA,M.FUJIWARA.Journal of Veterinary Pharmacology and Therapeutics . 2008 (3)Orito K, Saito M, Fukunaga K, Matsuo E, Takikawa S, Muto...