The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple ro...
Identification of a recurrent trans- forming UBR5-ZNF423 fusion gene in EBV-associated nasopharyn- geal carcinoma. J Pathol 2013 Oct; 231(2):158-67; PMID:23878065; http://dx.doi.org/10.1002/path.4240G.T. Chung, R.W. Lung, A.B. Hui, K.Y. Yip, J.K. Woo, C. Chow, C.Y. ...
► Mutations of ZNF423 or CEP164 are causes of retinal-renal ciliopathies ► The gene products colocalize with TIP60 at both centrosomes and nuclear foci ► Knockdown of ZNF423 or CEP164 impairs DNA damage response signaling ► Knockdown of cep164 in zebrafish causes a ciliopathy phenot...
This article has beenupdated Abstract Abnormal functional changes in pulmonary artery smooth muscle cells are the main causes of many lung diseases. Among, autophagy plays a crucial role. However, the specific molecular regulatory mechanism of autophagy in PASMCs remains unclear. Here, we first demons...
一个新的锌指蛋白基因ZNF333 cDNA的分离及表达谱分析 维普资讯 http://www.cqvip.com
Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesitydoi:10.1007/s00125-017-4471-4Diabetologia - Subcutaneous adipocyte hypertrophy is associated with insulin resistance and increased risk of type 2 diabetes, and predicts its...
A genome-wide motif search at EBF1 target gene loci revealed that EBF1 and ZNF423 co-regulated genes often contain SMAD1/SMAD4-binding motifs as exemplified by the TGFB1 promoter, which was repressed by ZNF423 outcompeting EBF1 by depending on its ability to bind EBF1 consensus sites and ...
A kit useful for such a method is also provided. In addition, the present invention provides a method for treating nasopharyngeal cancer by eliminating UBR5-ZNF423 gene expression or activity.Kwokwai Lo
A novel gene fusionRUNX1/ZNF423promotes leukemic relapse ofNUP98-rearranged AMLdoi:10.1038/s41375-023-02024-6Nature Publishing Group UKLeukemia
The ZNF521 mRNA instead was abundant in all primary chondrocytes studied; the RNAi-mediated silencing of this gene significantly altered the COL2A/COL1 expression ratio, associated with the maintenance of the differentiated phenotype, in chondrocytes cultivated in alginate beads. These results suggest ...