WT1 gene was examined by PCR and direct sequencing. The result showed that in the early-group 6/36 (16.7%) were detected with WT1 mutations. Further analysis according to different onset age revealed that the mutation detection rates of WT1 were 26.3% (5/19), 6.3% (1/16), and 0 (0...
wt1基因检测14是指采用基因测序技术，通过靶向检测wt1基因编码的N蛋白14号外显子的拷贝数变化来辅助诊断...
81966委纠犬硕士学位论文(2004届)血液系统肿瘤中、)VTl基因突变及启动子区域DNA甲基化的研究Study013WTlGeneMutationandItsPromoterRegionDNAMethylationStatusinHematologyNeoplasms研究生姓名..**竖指导教师姓名..睦**专业名称由i蜓鎏芏研究方向—J型坐啦必鱼鲢业韭L一论文提变日期2QQ4±!Q旦血液系统肿瘤中wTl基因...
基因名:WT1 别名:AWT1,EWS-WT1,GUD,NPHS4,WAGR,WIT-2,WT33 基因ID:7490 Chromosome: (GRCh37)11Start:32409321End:32457176Strand:-1 信号通路:肿瘤干细胞 靶向药: 化疗药:阿糖胞苷柔红霉素 WT1 基因突变与药物 EXON 7 MUTATION EXON 9 MUTATION
WT1 基因突变EXON 9 MUTATION Allele Registry ID:别名: ClinVar ID: WT1外显子9突变在急性髓性白血病中被证明是复发性的,尽管其发生率低于其外显子7突变。许多来源已经研究了这些基因的预后影响,一致认为突变外显子9队列与更差的总生存率和一些不良预后相关。这可能是由于wt1突变肿瘤对化疗反应不佳所致。
8,Hosoya N,Miyagawa K,Mitani K,et al.Mutation analysis of the WT1 gene in myelodysplastic syndromes.Jan J Cancer Res 1998,89:821-824. 9,Inoue K,Ogawa H,Yamagami T,et al.Long-term follow-up of minimal residual disease in leukemia patients by monitoring WT1 expression levels.Blood,1996,88...
Homozygous deletions in Wilms' tumor DNA have been a key step in the identification and isolation of the WT1 gene. Several additional loci are also postulated to contribute to Wilms' tumor formation. To assess the frequency of WT1 alterations we have analyzed the WT1 locus in a panel of 77 ...
目的采用Meta分析的方法总结近十年WT1突变与急性髓系白血病(AML)预后的关系.方法检索PubMed数据库,英文检索词为'WT1 mutation'和'Acute Myeloid Leukemia',检索中国知网(CNKI),万方数据库(WanFang),中文检索词为'WT1突变''急性髓系白血病',检索时间为2006年1月1日至2015年12月31日.结果本研究共纳入5篇英文文献,样...
Study on WT1 Gene Mutation and Its Promoter Region DNA Methylation Status in Hematology Neoplasms; 血液系统肿瘤中WT1基因突变及启动子区域DNA甲基化的研究 11. The Expression of WT1 Gene in Acute Leukemias and Its Clinical Implications; WT1基因在急性白血病的表达及其治疗意义的研究 12. The Role of ...
We tested this hypothesis by screening the WT1 gene for mutation in 12 46,XY patients with various forms of genital abnormality. Using single strand conformation polymorphism (SSCP) we did not detect any WT1 mutations in these patients. However, in addition to the 12 patients, three DDS ...