The Wilms tumor gene WT1, a proposed tumor suppressor gene, has been identified based on its location within a homozygous deletion found in tumor tissue. The gene encodes a putative transcription factor containing a Cys/His zinc finger domain. The critical homozygous deletions, however, are rarely...
Figure . Gene Sequencing (extract) Figure. SDS-PAGE [ IMPORTANT NOTE ] The kit is designed for research use only, we will not be responsible for any issue if the kit was used in clinical diagnostic or any other procedures. 特别提示:本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非...
The WT1 gene was originally defined as a tumor suppressor gene involved in the etiology of Wilms’ tumor [30]; however, it also manifests oncogenic activities[31–33]. The WT1 gene encodes a zinc finger transcription factor, WT1, which has been identified as a potent transcriptional regulator...
and can act as an oncogene or a tumor suppressor. It exerts influence over the epigenetic landscape, and also has post translational influence of gene expression through RNA interactions. The diverse biological roles of WT1 have been attributed to the existence of multiple isoforms and post translat...
As there is no apparent SRY orthologue in platypus, another gene must acquire the function of a key regulator of the gonadal male or female fate. SOX9 was ruled out from being this key regulator as it maps to an autosome in platypus. To check whether other genes in mammalian gonadogenesis...
gene locus and consequentlyLacZ-reporter expression would not be expected to precisely mimic endogenous gene expression and instead overlap in-part withWt1in the developing embryo31,32(Fig. 3a–i;Supplementary Figs 4,5). The −42 bp ECR, which based on its genomic location (Fig. 2a) is...
products gene name : WT1 other gene names : WT1; WT1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2 uniprot entry name : WT1_HUMAN clonality : Monoclonal isotype : IgG1/K clone : 6F-H2 host : Mouse reactivity : Human form : WT1 is a mouse monoclonal antibody derived from cell culture su...
Map Location 2 E3; 2 55.06 cM Pathway [[Pathway]] Gene Summary This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the ...
The Wilms' tumor gene (WT1) is an essential gene for kidney and gonadal development, although how WT1 expression is induced in these tissues is not known. One kidney transcription factor likely to play a role in this regulation is PAX 8. The co-expression of WT1 and PAX 8 during kidney ...
The present status of the gene map as well as some of the methods and strategies important for future efforts in completing the gene map of are reviewed. R Fries,JS Beckmann,M Georges,... - 《Animal Genetics》 被引量: 205发表: 1989年 The cDNA sequence and chromosomal location of the hu...