The Wilms' tumour suppressor gene WT1 encodes a zinc finger protein that is mutated in a subset of Wilms' tumours. Mutation screening and animal studies revealed essential roles during development and later function of the kidneys and the entire genitourinary system. Sequence similarity suggested a ...
gene 复序列 PCR polymerase chain reaction 聚合酶链反应 CN CN-AML cytogenetically normal myeloid leukemia acute 正常核型急血病 CR complete response 完全缓解 RFS OS relapse-free survival overall survival 无复发生存总生存急性髓系白血病患者 WT1 基因多态性的分布及其临床意义学位申请人:王海霞导 师:刘新月 ...
Ladomery,New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes,Am J Physiol Renal Physiol 295: F12–F17, 2008. [8]Rafael S. Lindoso, Karine S. Verdoorn and Marcelo Einicker-Lamas,Renal recovery after injury: the role of Pax-2,Nephrol Dial Transplant 24: ...
Ladomery,New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes,Am J Physiol Renal Physiol 295: F12–F17, 2008. [8]Rafael S. Lindoso, Karine S. Verdoorn and Marcelo Einicker-Lamas,Renal recovery after injury: the role of Pax-2,Nephrol Dial Transplant 24: ...
wt1蛋白中的一些多肽可以被hla分子呈递到细胞表面并被t细胞识别。hla-a11限制性wt1蛋白t细胞表位的鉴定和tcr的发现对于靶向wt1的免疫治疗具有重要意义。[0008]发明人通过特异性t细胞受体(tcr)单细胞筛选技术,筛选出特异性靶向于肿瘤相关抗原wt1的上述表位的tcr。[0009]本发明的一个实施方式包括提供了靶向肿瘤相关抗原wt1...
The Wilms' tumor gene, WT1, encodes a zinc finger transcription factor which functions as a tumor suppressor. Defects in the WT1 gene can result in the development of nephroblastoma. WT1 is expressed during development, primarily in the metanephric kidney, the mesothelial lining of the abdomen ...
[ 1]. Cancer cells are self-cells with aberrant growth potential, acquired as a result of several gene abnormalities [ 2]. The idea that the immune system could control cancer growth has been discussed for over a century. “Evading immune destruction” has been recently added in the ...
Nuclear WTIP may reprogram WT1-dependent gene expression to facilitate a podocyte phenotype switch that promotes cell survival until an injury is terminated.doi:10.1096/fasebj.22.1_supplement.1218.9Jane H KimPhysiology and BiophysicsAmitava Mukherjee...
【关键词】逆转录聚合酶链反应;腺癌;基因,wnReal—timefluorescencequantitativeRI'一PCRdetectionofWT1geneexpressionincolorectaladenocarcinomaXUn,HE肌,XUYong-qun,WANGHong-wei.*DepartmentofPathology,ShanxiMedicalUniversity,Taiyuan03O001.China【Abstract】0bjectiveToevaluatetheexpressionofWT1incolorectaladenocarcinomaand...
Cancer cells are self-cells with aberrant growth potential, acquired as a result of several gene abnormalities [ 2]. The idea that the immune system could control cancer growth has been discussed for over a century. “Evading immune destruction” has been recently added in the hallmarks of ...