WNT signaling can be divided into two pathways: canonical and non-canonical. The canonical WNT pathway leads to regulation of gene transcription by β-catenin, whereas the non-canonical WNT pathway regulates the cytoskeleton in cell morphology63. Several studies have revealed that disruption of ciliat...
The Wnt signaling pathway is intricately connected with bone mass regulation in humans and rodent models. We designed an antibody-based platform that generates potent and selective Wnt mimetics. Using this platform, we engineer bi-specific Wnt mimetics that target Frizzled and low-density lipoprotein ...
Wnt signaling pathway in CRC Wnt pathway has been reported to orchestrate differentiation and development of metazoan via modulation of the key transcriptional framework [6]. Both canonical and non-canonical signaling of the Wnt Pathway contributes to the development and differentiation [11]. In case...
Based on additional experimental data, the Wnt/β-catenin pathway, critical to induction of osteoblast differentiation and activity, is postulated to also have a direct inhibitory role in OC differentiation. (Diagram format derived from References 37 and 48). First, we documented suppression of the...
Here, using multiplex immunoassay, we shown a decrease in PTEN and mammalian target of rapamycin (mTOR) kinase phosphorylation in A549 cells upon the rSLURP-1 treatment pointing on down-regulation of the PI3K/AKT/mTOR signaling pathway. Decreased phosphorylation from the platelet-derived development ...
Wnt1沉默树突状细胞趋化因⼦来诱导肺腺癌的适应性免疫耐受Wnt1 silences chemokine genes in dendriticcells and induces adaptive immune resistance in lung adenocarcinoma Dimitra Kerdidani 1,2, Panagiotis Chouvardas 1,3,4, Ares Rocanin Arjo5, Ioanna Giopanou 6,Giannoula Ntaliarda6, Yu Amanda Guo7,...
Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer 2023, Journal of Translational Medicine Mechanism of cancer stemness maintenance in human liver cancer 2022, Cell Death and Disease The Wnt/β-catenin signaling pathway in the...
Interferon‐gamma regulates intestinal epithelial homeostasis through converging beta‐catenin signaling pathways. Immunity. 2010;32:392‐402. 34. Jang J, Jung Y, Chae S, Chung SI, Kim SM, Yoon Y. WNT/beta‐cat- enin pathway modulates the TNF‐alpha‐induced inflammatory re...
The TGF-β and Wnt signaling pathways are interrelated in many cell types and tissues, and control cell functions in coordination. Here, we report that SMAD4, a downstream effector of the TGF-β signaling pathway, induces FZD4, a receptor of the Wnt sign
c, Sankey diagram showing the contribution of stromal cells from each tissue type to the clusters shown in b. Colours and labels for sampled tissue as in a (left) and subclusters as in b (right). d, Heat map of the top 5 genes expressed in each stromal subcluster shown in b. ...