In the adhesive pool, β-catenin acts as the core component of the AJs and regulates the aggregation of cadherin by directly binding to the cytoplasmic domain of E-cadherin and the actin-binding protein α-catenin, maintaining cell–cell junctions, tissue structural integrity, and homeostasis [11...
improvement, lobulation, and/or pseudopodium indication, we ought to contemplate it could be the CNS-RDD. Procedure is a vital and effective treatment for CNS-RDD. Steroids and chemotherapy are effective and safe for the postoperative remedy for relapsing instances or residual lesions. The pool...
Pooled supernatants from 4 to 6 valves were spun at 800 rpm, and the cell pellet was resuspended in 3 ml of complete M199 culture medium containing 10% fetal bovine serum (Hyclone) plus penicillin/streptomycin (Invitrogen). The cells were plated on collagen-coated 2-well permanox chamber ...
Leukaemia stem cells (LSCs) underlie cancer therapy resistance but targeting these cells remains difficult. The Wnt–β-catenin and PI3K–Akt pathways cooperate to promote tumorigenesis and resistance to therapy. In a mouse model in which both pathways a
We suggest that the use of two spatially separated signaling systems to initiate the JAK-STAT stem cell maintenance pathway in germ cells provides a mechanism for increasing the pool of potential progenitors of the germline stem cells in the adult testes. Finally, we present evidence indicating ...
K14ΔNβ-cateninER cells were excluded if more than two neighbouring cells were also CellTracker+. Fluorescence intensity distributions from biological and technical replicates were pooled and contrasted between conditions using the non-parametric Kolmogorov–Smirnov test....
Previous work has demonstrated expression of Wnt5A, Wnt2B and Wnt10B in pooled human BM populations [26]. However, the expression pattern of Wnt ligands, Fzd receptors and Wnt antagonists in human B lineage cells has not been explored. In the absence of available antibodies to detect these ...
Our results confirm that secreted Wnt ligands are essential for maintaining intestinal homeostasis via renewal of the stem cell pool. In the intestine, Wnt ligands are secreted from the epithelium by Paneth cells and possibly also by extra-epithelial cells (Durand et al., 2012, Farin et al., ...
(Wza and YiaD) immunization led to a synergistic immune reaction. • Capsular polysaccharides pool caused up to 90% protection of tested clinical isolates. • The pentavalent pool showed superiority with 100% success of immunized mice.Human stem cellular element (hSCF) is an early-acting ...
D. et al. Conditional stabilization of beta-catenin expands the pool of lung stem cells. Stem Cells 26, 1337–1346 (2008). Article CAS PubMed PubMed Central Google Scholar Xi, Y. et al. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat. Cell Biol. ...