To identify the most important parameters associated with cerebral white matter hyperintensities (WMH), in consideration of potential collinearity, we used a data-driven machine-learning approach. We analysed two independent cohorts (KORA and SHIP). WMH volumes were derived from cMRI-images (FLAIR)....
Premature-born adults exhibit lasting white matter alterations as demonstrated by widespread reduction in fractional anisotropy (FA) based on diffusion-weighted imaging (DWI). FA reduction, however, is non-specific for microscopic underpinnings such as aberrant myelination or fiber density (FD). Using ...
Initial study of magnetic resonance diffusion tensor imaging in brain white matter of early AIDS patients. BACKGROUND: HIV is a neurotropic virus which can cause brain white matter demyelination, gliosis, and other pathological changes that appear as HIV encepha... A Xuan,GB Wang,DP Shi,.....
Magnetic resonance imaging (MRI) based diffusion tensor imaging (DTI) can assess white matter (WM) integrity through several metrics, such as fractional anisotropy (FA), axial/radial diffusivities (AxD/RD), and mode of anisotropy (MA). Standard DTI is susceptible to the effects of extracellular...
despite growing post-mortem evidence20and recent in vivo data implicating tau in spatially dependent white matter deficits21. The interpretation of FA and MD is further complicated by their sensitivity to multiple microstructural injury, not least including axonal loss, demyelination, and gliosis22. ...
our unifying physics-driven damage model explains pvWMHs locations and is supported by histopathological studies on ventricle surface gliosis81and the observation of decreased white matter integrity82. Moreover, our model and damage hypothesis provide a rational for the different stages of pvWMHs as ...
White matter disease This article is cited by A fully automated and explainable algorithm for predicting malignant transformation in oral epithelial dysplasia Adam J. Shephard Raja Muhammad Saad Bashir Nasir M. Rajpoot npj Precision Oncology(2024) ...
Figure 3. Stereotactic brain biopsy of the subcortical white matter. (A) Haematoxylin and eosin (H&E) stained sections show white matter oedema, perivascular and parenchymal inflammation and reactive gliosis. (B) CD138 immunohistochemistry highlights numerous plasma cells, and (C) CD163 demonstrates...
Eight studies highlighted the presence of gliosis in the white matter in 37 DM1 patients overall, although the type of gliosis was mostly not specified (e.g., reactive astrogliosis, microgliosis/activated microglia cells, or oligodendrocyte response). The largest study among these eight ...