21-24 However, these lesions are not specific to MS and must be differentiated from others such as those of ischemic white matter lesions or normal aging.22-24 The MS lesions often have irregular outlines, a lumpy-bumpy appearance, small size, and a characteristic radial orientation.22-24 ...
Complement peptide C3a promotes astrocyte survival in response to ischemic stress. Mol Neurobiol. 2016;53:3076–87. CAS PubMed Google Scholar Weerth SH, Rus H, Shin ML, Raine CS. Complement C5 in experimental autoimmune encephalomyelitis (EAE) facilitates remyelination and prevents gliosis. Am...
However, improving curcumin’s bioavailability is not a trivial task, and careful analysis of effects in brain and on behaviour are required for new formulations because micromolar levels may be deleterious due to curcumin’s well-known capacity to inhibit the proteasome. Moreover, it has been ...
Neuroinflammation is also involved in the complex cascade leading to AD pathology and symptoms. It has been shown that AD is associated with increased levels of cycloxygenase 1 and 2 and of prostaglandins, release of cytokines and chemokines, acute phase reaction, astrocytosis and microgliosis [...