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Using MDA-MB-231 cells as a model of triple negative breast cancer (TNBC) and its metastatic sub-cell lines that preferentially metastasize to lung, bone or brain, we found that the mRNA and protein levels of fibronectin (FN) are increased in MDA-MB-231
Santa Cruz), 60 nM SNAI1 siRNA-1 (GCAAAUACUGCAACAAGGA, D-010847-01, Dharmacon, TX), 60 nM SNAI1 siRNA-2 (GCUCGGACCUUCUCCCCGAA, D-010847-03, Dharmacon, TX) for 48-h using Lipofectamine 2000 reagent (Invitrogen, Carlsbad, CA). Cells were then subjected to SNAI1gene expression analys...
IFI16 DNA damage DNA repair type-I IFN cytosolic DNA STING triple-negative breast cancer antitumor immunity Introduction Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer-related death in women worldwide (Torre et al., 2017). Accounting for 15% to 20% of tot...
This study was approved by the institutional review boards of the NDMC (IRB number: TSGHIRB-099-05-058). All participants signed an informed consent. Additionally, we downloaded and processed TCGA breast cancer mRNA expression data from 2007 tumors and relevant adjacent normal tissue controls from...
Breast cancer cells affected by mutation in BRCA1/2 genes are deficient in the DNA for double-strand breaks (DSB) repair. Indeed, both BRCA1 and BRCA 2 are key components in homologous recombination repair (HRR), the major pathway to repairing the double-strand damage [38]. The PARP ...
PARPi traps PARP1 and induces cell death by preventing single-stranded break repair, followed by double-stranded breaks without functional homologous recombination in patients with BRCA mutations [6]. Talazoparib has been approved for patients with locally advanced or metastatic, HER2-negative breast ...