In different populations, such as congestive heart failure patients, treatment of ID leads to better clinical outcomes and HRQOL. However, the impact of ID on HRQOL is previously unknown among NDD-CKD individuals. We analyzed real world data from a multinational cohort of NDD-CKD stage 3 to 5...
saturation of transferrin with iron is calculated by dividing the serum iron concentration by the TIBC and multiplying by 100. Serum TIBC is low-normal or decreased in association with inflammatory disorders (Feldmanet al., 1981b;Ottenjannet al., 2006;Smith and Cipriano, 1987) and increased in...
In addition to the density of TRs on the tumor cell surface, the efficacy of Tf-toxin conjugate is influenced both by the Tf-iron saturation state and by the presence of free diferric Tf in the tumor microenvironment. The affinity of Tf-Saporin (Tf-SO6) to TR was greatly diminished whe...
After a 6-week treatment with an anti-transferrin antibody, a decrease in transferrin plasma concentration was observed (Supplementary information, Fig.S10a). This was accompanied by a relative decrease in the enzymatic activities of thrombin (Supplementary information, Fig.S10b) and FXIIa (Supplemen...
Effect of low and moderate doses of recombinant human erythropoietin on the haematological response in premature infants on a high protein and iron intake saturation indicated no iron deficiency, soluble transferrin receptor increased in both groups, more rapidly and to higher levels in the 100 IU/...
Few data exist to guide treatment of anemic hemodialysis patients with high ferritin and low transferrin saturation (TSAT). The Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) trial was designed to evaluate the efficacy of intravenous ferric gluconate in s...
Method Ferritin, transferrin, iron, transferrin saturation (TSAT) and hepcidin were measured in baseline, pre-treatment, serum samples from 202 randomly selected patients with severe alcoholic hepatitis (AH) recruited prospectively via the STOPAH trial. Hepatic transferrin mRNA expression was assessed ...
treatment responsePlasmodium falciparumfever clearancehaematologyThe diagnosis of iron deficiency anemia (IDA) in the elderly is difficult because of the prevalence of chronic diseases, which can cause anemia with high ferritin levels, even in the presence of iron deficiency. Therefore, we studied the...
Transferrin saturation (%) 24.9 ± 16.8 19.5 ± 10.8 0.042 Ferritin (ng/ml) 229 ± 199 384 ± 516 0.279 Glucose (mg/dl) 107.3 ± 27.2 99.5 ± 14.7 0.094 Serum creatinine (mg/dl) 9.5 ± 1.9 9.7 ± 2 0.608 Serum albumin (g/dl) 3.8 ± 0.4 3.7 ± 0.5 0.371 C-reactive protein (...
After CDT was first introduced in the 1970s as a more specific alcohol biomarker than the established tests, it has become widely used in different settings for routine detection of heavy alcohol consumption and follow-up of treatment, and as an objective outcome measure in a large numbe...