with high concentration clotting factors, i.e., fibrinogen and AT, but also with low concentration clotting factors, i.e., coagulation proteases. In AS, up-regulated transferrin interacts with and potentiates thrombin/factor XIIa (FXIIa) and blocks AT’s inactivation effect on coagulation proteases...
Even if patients with hemochromatosis maintain low serum levels of ferritin, they still have an increased risk of general and joint symptoms, which reduce quality of life. This could be related to persistently increased transferrin saturation. We assessed whether duration of exposure to increased ...
Importantly, serum Tf levels we measured in the experimentally-induced High and Low TSAT rats doubled those of normal rats (8.67 ± 0.89, 8.61 ± 0.57 and 4.10 ± 0.27 mg/ml, respectively), this proving that serum Tf saturation with iron, rather than Tf levels, determines the growth and...
P0849LOWER TRANSFERRIN SATURATION INDEX (TSAT) IS ASSOCIATED WITH WORSE HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN NON-DIALYSIS DEPENDENT CHRONIC KIDNEY DISEASE (NDD-CKD) PATIENTS AT BOTH HIGHER AND LOWER HEMOGLOBIN LEVELSBACKGROUND AND AIMS. Iron Deficiency (ID) is a common condition in NDD-...
Also, Tfr2α localizes in lipid raft domains on the exosomal cell membrane, where it is internalized by clathrin-mediated endocytosis, if transferrin saturation (TS) is low [49]. Tfr2α protein regulation occurs mainly through its stabilization on the cell membrane as a consequence of the ...
These patients have either normal or high serum ferritin levels, but present a frankly decreased transferrin saturation. It is therefore of paramount importance to screen functional iron deficiency—which usually responds to iron therapy—from the so-called inflammatory iron block, which is insensible ...
transferrin saturation index; HB, hemoglobin; sTfR, soluble transferrin receptor; HEP, hepcidin. Continuous variables are expressed as the medians and interquartile ranges (IQR). Categorical variables are expressed as numbers and percentages. Differences between variables and groups were determined by usi...
Notwithstanding that superfluous iron is preferably deposited in the liver parenchyma, other parenchymatous tissues may be targeted as well, and malfunction might be expressed as (mild) diffuse clinical symptoms or an increase in disease-specific symptoms. Even if this is difficult to prove, the pot...