Previously, it was shown that the integrin β1 subunit was required for activation of latent TGF-β1 and skin fibrosis. A recent study by Henderson and colleagues (Nature Medicine 19,1617-1624, 2013) used three different in vivo models of fibrosis to show that integrin αv subunit was ...
TGF-β1 is a main inducer of epithelial to mesenchymal transition (EMT). However, many breast cancer cells are not sensitive to the EMT induction by TGF-β1 alone. So far, the mechanisms underlying the induction of TGF-β1-insensitive breast cancer cells remains unclear. Here we report that...
( 2004 ) The Plasmodium circumsporozoite protein is involved in mosquito salivary gland invasion by sporozoites . Mol Biochem Parasitol 133 : 53 – 59 .Myung, J.M. , Marshall, P. , and Sinnis, P. ( 2004 ) The Plasmodium circumsporozoite protein is involved in salivary gland invasion by ...
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Myeloid lineage cells present the latent form of transforming growth factor-β1 (L-TGF-β1) to the membrane using an anchor protein LRRC33. Integrin αVβ8 activates extracellular L-TGF-β1 to trigger the downstream signaling functions. However, the mech
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