As Src is activated by various oxidative stimuli and TGF-β reportedly stimulates H2O2 production, we hypothesize that TGF-β activates Src through a redox dependent mechanism. We found that TGF-β exposure increased Src phosphorylation at Tyr419 (pTyr419 Src), but also at Tyr530 (pTyr530 Src...
Endoglin forms a protein complex with the TGF-β types I and II HHT THERAPEUTIC APPROACHES. MOLECULAR MECHANISMS OF ACTION So far, there is no cure for HHT and there is a need to find an effective drug for its treatment. The pharmacological therapeutic strategies should be ideally aimed at:...
In fibrotic tissues, TGF-β drives not only enhanced fibroblast activation but it also modulates immune surveillance. Once these pathways are activated, the result is neoplastic transformation and cancer cell survival. The intersection of these pathways underscores the pivotal role of TGF-β signaling ...
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Before surgery, breast cancer patients had somewhat higher sTGFβrIII than healthy women, or those with benign breast lesions (by 14.5 and 26 ng/mL, respectively), with a tendency of larger differences at higher age. This correlated with lower expression of TGFβrIII in breast cancer vs. ...
In pathologies including cancer, aberrant Transforming Growth Factor-β (TGF-β) signaling exerts profound tumor intrinsic and extrinsic consequences. Intense clinical endeavors are underway to target this pathway. Central to the success of these interve
et al. Eosinophils enhance WNT-5a and TGF-β1 genes expression in airway smooth muscle cells and promote their proliferation by increased extracellular matrix proteins production in asthma. BMC Pulm Med 16, 94 (2016). https://doi.org/10.1186/s12890-016-0254-9 Download citation Received04 ...
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