RA外泌体中的几种miRNA比来自健康对照供体的外泌体中丰度更高。在RA患者中上调的miRNA中,miR-17可通过抑制转化生长因子β受体II(TGFBR II)的表达来抑制Treg诱导。研究结果表明,RA外泌体中miRNA表达的改变可能通过破坏Tregs的体内平...
TGFBRIIand TGFBRIIII)polymorphismFACTOR-BETAPolymorphism of genes of transforming growth factor TGFB and its receptors (TGFBRI, TGFBRII, and TGFBRIIII) in patients with primary open-angle glaucoma was analyzed. The frequency of the TGFBRII CC genotype in patients is increased relative to the ...
RepSox也称为 SJN 2511、E 616452 和 ALK5 Inhibitor II,是一种可渗透细胞的选择性 TGF-β 1 型激活素样激酶受体 ALK5 抑制剂(对 ALK5 自磷酸化的 IC50s = 4、18 和 23 nM,TGF- β 细胞测定和 HepG2 细胞中的 ALK5 结合)。 RepSox 减缓 CD34+ 急性髓性白血病细胞的衰变并降低 T 细胞免疫球蛋白...
Microsatellite instability and mutations of TGFBRII,IGFIIR and BAX gene in colorectal carcinoma with extracellular mucus secretionrupture of the spleenacute pancreatitischronic pancreatitissplenectomypancreatectomyBackground: Accessory spleen is a common congenital ano...
Antibody or human tgfbrii-binding fragment thereof, pharmaceutical compositions comprising them and use thereof in the manufacture of medicaments for inhibiting angiogenesisThe present invention is directed to antibodies against human transforming growth factor beta receptor II (TGFRII), pharmaceutical ...
The present invention relates to TCR molecules which recognise neopeptides produced as a result of the cancer-associated "−1A" frameshift mutation in human TGFβRII. The TCR molecules are capable of binding a peptide of SEQ ID NO: 1 when said peptide is presented by a Class I MHC, and...
No TGFBRII germline mutations in juvenile polyposis patients without SMAD4 or BMPR1A mutation. Gut. 2009; 58:154-156. [PubMed: 19091845]Brosens LA,van Hattem WA,Kools MC,Ezendam C,Morsink FH,de Leng WW,Giardiello FM,Offerhaus GJ.No TGFBRII germline mutations in juvenile polyposis ...
GENETICALLY ENGINEERED T CELLS WITH REGNASE-1 AND/OR TGFBRII DISRUPTION HAVE IMPROVED FUNCTIONALITY AND PERSISTENCEA population of genetically engineered T cells, comprising a disrupted Reg1 gene and/or a disrupted TGFBRII gene. Such genetically engineered T cells may comprise further genetic ...
Age-related changes in wild-type (WT) and DNTGFBRII mice, from 8 to 14 weeks of age (8W and 14W, respectively).Cintia, S. de Paiva
Cellular uptake inhibition experiments with soluble fiber knob protein and TGFBRII-specific antibody.Tanja LucasKarim BenihoudFrederic VigantChristoph Q. Andreas SchmidtMax G. BachemThomas SimmetStefan Kochanek