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Our findings suggest the phenotypic effects of the genetic mutation largely outweighed the effects of thyroxine exposure in the Twist 1 +/− model. These results highlight difficultly in experimentally modeling gene-environment interactions for craniosynostotic phenotypes....
Birth defects research, Part A. Clinical and molecular teratologyDurham EL, et al. Effects of thyroxine exposure on the Twist 1 +/- phenotype: A test of gene- environment interaction modeling for craniosynostosis. Birth Defects Res A Clin Mol Teratol. 2016; 23543....