Gain & Meaning by: Lynn R. Millerfrom issue: 26-2 Editorials Gain always points to increase reflecting back on fertility. The word ‘gain’ in the manner to which I prefer its use and application NEVER, by definition, depletes. Whether you accept my terminology or not, it should be clea...
meaning that they do not function by blocking the active site of NS5B like a competitive inhibitor, but rather they work by binding to a different area on the protein and causing a conformational change that disrupts its function. Typically...
The term “small molecules” means different things to different scientists and the meaning has also changed over time. It is therefore important to define what a small molecule is in this review. Here it is taken to be any molecule with a molecular weight under 2000 g/mol in its native ...
Notably, our findings were also observed in Anle138b-treated unseeded neurons, meaning that the inferred processes are independent of tau pathology and thus represent the direct action of the compound in the cellular system. Through structure-based ligand-target prediction, we predicted the ...
Little did people realize that he only got the role in the opera because the director had heard William singing while out buying a newspaper.【1】What is the closest meaning of the word “weird” in Paragraph 1A.commonB.unusualC.fairD.surprised【2】At first, what did people in ...
The diverse activity of ebselen may be related to its electrophilic nature, meaning that it could interact with cysteine-rich proteins. In fungal cells, the antifungal activity of ebselen was associated with the inhibition of plasma membrane H+-ATPase, regulation of glutathione (GSH), and reactive...
The bioavailability scores for all hit compounds were 0.55 meaning that the compounds may have >10% bioavailability in rat (Martin, 2005). Therefore, these values indicated that the hit compounds may have good absorption and distribution properties. The cytochrome P450 (CYP2D6) is a key enzyme ...
(spinterns) up to 2cm in length, densely clustered over the surface. The spinterns vary in color, but are usually red with green tips and are responsible for the common name of the fruit, which is based on the Malay word ‘rambut,’ meaning hair. The flesh or aril is white or rose...
The chemically modified small molecules described herein relate to and/or have application(s) in the fields of drug discovery, pharmacotherapy, physiology, organic chemistry, polymer chemistry, and others. BACKGROUND OF THE INVENTION The use of proteins as active agents has expanded in recent years...
37. A compound of the formula (A): wherein n is an integer from 0-4; q is an integer from 0-1; X is ═O or —O—R3; R1 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl...