Background Sickle cell disease (SCD) is commonly encountered in Africa and Middle Eastern countries. The causative mutation in the gene encoding the hemoglobin subunit 尾 (HBB) leads to various genotypic variants of the disease. This results in varied phenotypes, with a spectrum of complications, ...
Sickle cell disease is any syndrome with a sickle mutation that alters normal beta globin: Determined by specific allelic pairings Autosomal recessive inheritance Homozygous genotype = HbSS ; causes sickle cell anemia Heterozygous condition = HbSA ; benign carrier condition called “ sickle cell tr...
Sickle cell syndromes, also collectively referred to as sickle cell disease (SCD), are generic terms for a group of chronic inherited disorders of hemoglobin structure in which the affected individual inherits two mutant globin genes (one from each parent), at least one of which is always the ...
Sickle cell disease (SCD), is an autosomal recessive hemoglobin disorder that results from the replacement of glutamate for valine at the sixth amino acid of the beta-globin chain. This replacement results in the formation of hemoglobin S (HbS) tetramers that accumulate during oxidative stress, t...
Sickle cell disease can be caused by multiple genetic variants. Most estimates of sickle cell disease burden account only for the homozygous HbSS variant, which excludes mortality and morbidity caused by the HbSC variant or thalassaemia. Inclusion of HbSC and thalassaemia would add a further 130 ...
Sickle cell disease is an autosomal recessive disorder of a gene mutation. On chromosome 11, nucleotide mutation leads to substituting glutamic acid to valine at position 6 on the β-globin subunit. This leads to changes in the physical properties of the globin chain. Many inciting factors lead...
1 Cost-effectiveness of l-glutamine versus crizanlizumab for adults with sickle cell disease: model focused on reducing pain episode costs from Qatar's healthcare perspective. l - 谷氨酰胺与 crizanlizumab 治疗成人镰状细胞病的成本效益 : 从卡塔尔的医疗保健角度出发 , 模型侧重于减少疼痛发作成本。
P. (1983), Abnormalities of Serum Transcobalamins in Sickle Cell Disease (HbSS) in Black Africa. Scandinavian Journal of Haematology, 30: 135–140. doi: 10.1111/j.1600-0609.1983.tb01459.x Author Information 1 Laboratory of Medical Biochemistry, Faculty of Medicine, University of Nancy, 54500 ...
Malaria is fatal in homozygous sickle cell (HbSS) disease. In a cross‐sectional s... JR Aluoch - 《Tropical Medicine & International Health Tm & Ih》 被引量: 59发表: 2010年 Sickle-cell disease of Africans in Kenya. This investigation is an attempt to explain the anomaly that whereas ...
Life expectancy in HbSS from a multicenter study in the USA in 1994 was estimated at 42 for men and 48 for women,8 and 95% of children survive to adulthood.9 The effect of sickle cell disease on infection Impaired splenic function The spleen has a key role in the increased susceptibility...