Hohhot010021,China)AbstractSmallRhoGTPaseproteinfamilyisamemberoftheRassuperfamily.ThehumanRhofamilyofsmal1GTPaseiScomprisedof20members,ofwhichRhoA,Rac1andCdc42arebest.studied.SmallRhoGTPasesareinvolvedinmanyimportantbiologicalprocesses,suchascellcytoskeletonregulation,cellmigration,cellproliferationandcellcycle...
This antiproliferative effect has been attributed to the ability of Rnd3 to antagonize RhoA by increasing p190 RhoGAP activity and to induce cell-cycle arrest at the G1 phase [119,120]. Each Rnd GTPase possesses a CAAX box that terminates with Met; as such, all Rnd proteins are farnesylated...
The ras homolog family member G (RHOG), also known as rho-related GTP-binding protein, is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transdu
Small G-protein RhoE is underexpressed in prostate cancer and induces cell cycle arrest and apoptosis. Prostate 2005 Sep 1;64(4):332-40.Bektic, J. et al. (2005) Small G-protein RhoE is underexpressed in prostate cancer and induces cell cycle arrest and apoptosis. Prostate 64, 332-340...
This step-wise analysis identified three broad functionalities "cell differentiation", "cell cycle" and "developmental process" (also listed in Table 6, results from integrated approach) but failed to identify other specific functionalities associated with the experiment. Assessing dye bias Dataset-2 ...
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, an...
The monomeric GTPase Rho regulates a variety of cellular processes, such as actin cytoskeletal rearrangement and gene expression. Two members of the heterotrimeric GTP-binding protein (G-protein) family, Gα 12 and Gα 13 , have been shown to mediate signals from G-protein coupled receptors lead...
The stromal reaction in pancreatic cancer creates a physical barrier that blocks therapeutic intervention and creates an immunosuppressive tumor microenvironment. The Rho/myocardin-related transcription factor (MRTF) pathway is implicated in the hyper-ac
Like other G proteins, small G proteins cycle between the GDP-bound inactive and GTP-bound active forms (1,2). They receive upstream signals through their regulators and transduce signals to downstream targets while they stay in the GTP-bound form. Thus, G proteins serve as timers. There ...
Here, we outline the contributions of H-RAS, N-RAS and K-RAS to cell-cycle progression and cell growth. We also summarize recent results that indicate how other members of the RAS-GTPase subfamily - including E-RAS, RHEB, R-RAS, TC21 and RAL, as well as RHO GTPases - promote ...