综述了Rho GTPase家族典型亚家族成员RhoA,Cdc42和Rac1在耳蜗毛细胞的表达以及这些小分子蛋白是如何参与耳蜗毛细胞纤毛束的形态发生和外毛细胞运动,并且这些小分子作为感音神经性耳聋治疗的药物靶点的研究现状。
Abstract 2146: The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor Rho family proteins are prominent members of the well-known Ras superfamily and are deeply involved in almost all the malignant behaviors of cancer. As Small GTPases, Rho proteins can cycle between active GTP-bound...
产品描述 ML141是Rho家族GTPase cdc42的一种有效的,选择性可逆非竞争性抑制剂,IC50为200nM。 信号通路 Cell Cycle 靶点 cdc42 - - - - IC50 200nM - - - - 体外研究 ML141通过诱导细胞死亡和抑制细胞分裂,增强TMX抑制细胞生长的能力。ML141也显著保护神经母细胞瘤免受二甲双胍诱导的凋亡损害。此外,...
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, an...
The most widely studied and best-characterized members are the three classical members, RhoA, Rac1, and Cdc42, and much of our current concepts of Rho GTPase function are based on their properties (Aspenstrom et al. 2007; Wennerberg and Der 2004). They act as bi-molecular switches that ...
Share on Facebook rho Thesaurus Medical Legal Financial Acronyms Encyclopedia Wikipedia rho (rō) n. The 17th letter of the Greek alphabet. See Table atalphabet. [Greekrhō,of Phoenician origin; seerʔšinSemitic roots.] American Heritage® Dictionary of the English Language, Fifth Edition. ...
[44]KMPER S, MARDAKHEH F K, MCCARTHY A, et al. Rho-associated kinase (rock) function is essential for cell cycle progression, senescence and tumorigenesis[J]. eLife, 2016,5:e12994. [45]WU Y H, SHU J H, HE C W, et al. Rock inhibitor y27632 promotes proliferation and diminishes ...
溶液配制5mg加入1.23ml DMSO,或者每4.07mg加入1ml DMSO,配制成10mM溶液。SC6565-10mM用DMSO配制。 生物信息: 产品描述ML141是Rho家族GTPase cdc42的一种有效的,选择性可逆非竞争性抑制剂,IC50为200nM。 信号通路Cell Cycle 靶点cdc42--- IC50200nM--- 体外...
产品描述 ML141是Rho家族GTPase cdc42的一种有效的,选择性可逆非竞争性抑制剂,IC50为200nM。 信号通路 Cell Cycle 靶点 cdc42 - - - - IC50 200nM - - - - 体外研究 ML141通过诱导细胞死亡和抑制细胞分裂,增强TMX抑制细胞生长的能力。ML141也显著保护神经母细胞瘤免受二甲双胍诱导的凋亡损害。此外,...
is by Regulation of Rho GTPase activity: in [21]);Rho GTPases cycle between inactive GDP-bound and activ^oweverj this GTP-bound conformations; the activation state is activity can be controlled by GAPs (reviewed in [11]), GEFs [12, 13], andaj-|-erecj to drive plasma membrane, which...