G.S. holds patents on the hemibody technology and has acted as a consultant to Veraxa Biotech GmbH. R.C.B. has acted as a consultant and/or adviser to Amgen, Avencell, Bristol-Myers Squibb Catalym, Janssen-Cilag, Novartis and Roche, and holds a patent for blinatumomab, from which he...
E., Casimiro, D., Gurunathan, S. & DeRosa, F. The promise of mRNA vaccines: a biotech and industrial perspective. NPJ Vaccines 5, 11 (2020). Article Google Scholar Jeyanathan, M. et al. Immunological considerations for COVID-19 vaccine strategies. Nat. Rev. Immunol. 20, 615–632 ...
MetalloendopeptidasesChromatography, Ion ExchangeRats, Sprague-DawleyChromatography, High Pressure LiquidMaleThe new chromatographic system Akta-Purifier 10 (Amersham-Pharmacia Biotech), scaled for preparative HPLC, was used for the purification of Substance P (SP) endopeptidase activity in the ventral tege...
J. Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on drug discovery. Pharmacol. Rev. 62, 265–304 (2010). Article CAS PubMed PubMed Central Google Scholar Swinney, D. C. Biochemical mechanisms of drug...
38.Reflections on 10 years of the FDA's breakthrough therapy designation 机译:FDA突破性疗法认定10周年回顾 作者:Mullard Asher 期刊名称:《nature reviews drug discovery》 | 2022年第4期 39.Enhancing base editor delivery 机译:增强基础编辑器交付 作者:Crunkhorn Sarah 期刊名称:《nature reviews drug...
statement. “As the fifth RNAi therapeutic developed by Alnylam to receive regulatory approval in less than four years, we believe Amvuttra represents an important milestone that brings us one step closer to achieving our P5x25 goals aimed at Alnylam’s transition to a leading biotech company....
Annette studied at Imperial College London, where she completed her medical degree and intercalated a BSc and PhD in Endocrinology. During her PhD, she worked on hypothalamic peptides in the control of reproduction, with a particular focus on the role of kisspeptins. Bringing with her an interes...
Membrane scaffold protein (or MSP) nanodiscs (cube-biotech.com) are among the most popular at present. They consist of two copies of the amphipathic membrane scaffold protein composed of repeated \(\alpha\)-helix-forming segments. Two MSPs together form adjacent “belts” surrounding the ...
, which contain two CRDs each with a distinct specificity15,43,44joined by a flexible linker peptide. Fig. 1: Structural classification of galectins. Galectins are classified into three different subfamilies on the basis of their structure:a, prototype galectins (GAL1, GAL2, GAL5, GAL7, ...
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