The biological activity of Ran is regulated by the chromatin-associated guanine nucleotide exchange factor RCC1, and the cytosolic GTPase activating protein RanGAP. Thus, distribution of the regulators inside or outside the nucleus defines the concentration of Ran路GTP across the Nuclear Pore Complex...
W. Ran GTPase cycle and importins α and β are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol. Biol. Cell 13, 4355–4370 (2002). CAS PubMed PubMed Central Google Scholar Timinszky, G. et al. The importin-β P446L dominant-...
RCC1, the chromatin-bound guanine-nucleotide exchange factor (GEF) for the small nuclear GTPase, Ran, is required for coordinating the onset of mitosis with S-phase completion in mammalian cells. Other defects in the Ran-GTPase network also result in disruption of cell-cycle processes such as ...
Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle? 来自 万方 喜欢 0 阅读量: 97 作者:Paul R Clarke a,Chuanmao Zhang a b 摘要: Ran is an abundant GTPase that is highly conserved in eukaryotic cells and has been implicated in many ...
The Ran GTPase cycle is required for yeast nuclear pore complex assembly. J Cell Biol, 2003, 160: 1041–1053 27 Haluska F G, Housman D E. Recent advances in the molecular genetics of malignant melanoma. Cancer Surv, 1995, 25: 277–292 2476 https://engine.scichina.com/doi/10.1360/...
1小G蛋白Ran核浆转运过程重要的组成成分在真核生物中,RanGTPase系统在调节核输入与输出中扮演中心角色。Ran以极其特别的GDP和GTP绑定形式通过蛋白质的相互转换来调节输入与输出。核浆转运是一个有规律的过程,包括许多重要的组成成分,RanGTPase,karyopheri(运输蛋白),核孔蛋白等[3]1.1RanGTPase作为GTP酶,有两种底物结合...
1) Ran GTPase Ran GTP酶2) GTPase Ran GTP酶Ran 1. The Roles of GTPase Ran in Nuclear Processes throughout the Cell Cycle; GTP酶Ran在细胞核运输、核分裂与重建中的作用3) GTPase GTP酶 1. The Dynamic Changes of Membrane Protein GTPase Activity of Peritoneal Macrophages and the Effects of...
, 24., 25.), the Ran (F35A) mutant did not cause cell cycle arrest. This was demonstrated in experiments where we examined the ability of cells expressing Ran (F35A), as well as vector control cells, and cells expressing wild type Ran and the Ran (T24N) mutant, to stimulate DNA ...
网络释义 1. 接蛋白 【gtpase】什么意思_英语gtpase在线翻译_有道词典 ... Tubulin GTPase 微管蛋白Ran GTPase接蛋白GTPase cycle 鸟苷酸 … dict.youdao.com|基于 1 个网页
系统标签: ran蛋白细胞周期调控gtp 2011年第56卷第30期:2472~2477.scichinacsb.scichina英文引用格式:LiuPW,QiM,RenHY.FunctionsofthesmallGTPaseproteinRanincellcycleregulation(inChinese).ChineseSciBull(ChineseVer),2011,56:2472–2477,doi:10.1360/972011-1206《中国科学》杂志社SCIENCECHINAPRESS评述专辑:娄成后教...