RAC2 is a small signaling G protein/GTPase which is part of the RAS superfamily of small GTP-binding proteins which regulate cell growth, actin cytoskeletal organization, cell proliferation, survival, cell cycle progression, gene transcription rgulation and the activation of protein kinases. RAC2 cy...
Finally, through association with GT-Pase-activating proteins, the GTP-bound small GTPase returns to an inactive GDP-bound form by hydrolysis of the bound GTP. Importantly, the events by which cell surface receptors orchestrate the activation of Rac are likely dependent upon the upstream activation...
Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiencyRho GTPases control a variety of cellular processes, including actin polymerization, integrin complex formation, cell adhesion, gene transcription, cell cycle progression, and ...
Cell cycle analyses showed reduced cell cycle activity in RAC2-depleted BCR-ABL leukemic cobblestones coinciding with an increased apoptosis. Moreover, a decrease in mitochondrial membrane potential was observed upon RAC2 downregulation, paralleled by severe mitochondrial ultrastructural malformations as ...
26, 27, 28 In neutrophils, Rho GTPases (eg, Rho, Rac, and Cdc42 [cell division cycle 42]) control a wide spectrum of cellular functions, including cytoskeletal organization, transcription, superoxide production, and cell growth and proliferation; however, their role in eosinophils has been ...
Cell Cycle ProteinsChromosome MappingMembers of the Rho/Rac/Cdc42Hs family of GTPases have been shown to participate in many aspects of the signaling of cell growth and differentiation. Although the biochemical properties of these GTPases have been extensively studied, very little is known about ...