例如细胞凋亡（Apoptosis）、程序性坏死（Necroptosis）、细胞焦亡（Pyroptosis），以及铁死亡（Ferroptosis）等...
铁死亡（ferroptosis）一词诞生于 2012 年，指的是一种铁依赖的 RCD，由不受限制的脂质过氧化和随后的...
此前有研究表明,FtMt可以在体外抑制erastin诱导的铁死亡。为阐明FtMt对I/R是否有保护作用,河北师范大学常彦忠教授研究团队在Cell Death &Disease杂志上发表论文“Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by i...
铁死亡(Ferroptosis):是最早由哥伦比亚大学Dr. Brent R.Stockwell在2012年提出的,一种铁依赖性的、细胞内脂质活性氧累积的、区别于凋亡、焦亡、自噬的新型细胞程序性死亡方式;其本质是谷胱甘肽的耗竭,谷胱甘肽过氧化物酶(GPX4)活性下降,脂质氧化物不能通过GPX4催化的谷胱甘肽还原酶反应代谢,之后二价的铁离子氧化脂质产生...
铁死亡(Ferroptosis):是最早由哥伦比亚大学Dr. Brent R.Stockwell在2012年提出的,一种铁依赖性的、细胞内脂质活性氧累积的、区别于凋亡、焦亡、自噬的新型细胞程序性死亡方式;其本质是谷胱甘肽的耗竭,谷胱甘肽过氧化物酶(GPX4)活性下降,脂质氧化物不能通过GPX4催化的谷胱甘肽还原酶反应代谢,之后二价的铁离子氧化脂质产生...
在探讨铁死亡这一话题时，我们注意到一篇发表于2022年2月在SCIENCE ADVANCES杂志上的文章，题为“Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion”。这篇文章通过深入研究地塞米松对铁死亡的敏感性，揭示了地塞米松通过糖皮质激素受体（...
Fe 2+，expression of ferroportin 1（FPN1），hepcidin and STAT3phosphorylation （p-STAT3）were increased in HT22cells of LPS group ，which was statistically signifi‑cant compared with the control group （P <0.01）.In CELE+LPS group ，cell viability was increased ，the level of ferroptosis ，...
(ferroptosis suppressor protein 1,FSP1)及溶质载体系列7成员(solute carrier family 7 member 11,SLC7A11)表达明显下调,而PTGS2,铁反应元件结合蛋白2(iron responsive element binding protein2,IREB2),转铁蛋白受体(transferrin receptor,TFRC)及酰基辅酶a合成酶长链家族成员4(Acyl-Co A synthetase long chain ...
RESULTS AND CONCLUSION: (1) A total of 30 differentially expressed ferroptosis-related genes were identified between the peripheral blood samples of steroid-induced osteonecrosis of the femoral head patients and non-steroid-induced osteonecrosis of the femoral head patients based on the def...
Stem cell membrane-coated siRNA of lncRNA Gm47283 increases miR-706 , and then miR-706 suppresses the expression of Ptgs2 to reduce lipid peroxidation toxicity, and then inhibits cardiomyocyte ferroptosis. PUFA: polyunsaturated fatty acid.Zhanfa Sun...