2024年9月11日 ,再生元制药公司Michael E. Dunn通讯在《Nature》发表论文“Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone”,研究了靶向利钠肽受体1(natriuretic peptide receptor 1, NPR1)在心力衰竭(HF)中的潜在治疗意义。该研究强调了NPR1在调节血压和静脉张力方面的重要性,并介绍了RE...
2024年9月11日 ,再生元制药公司Michael E. Dunn通讯在《Nature》发表论文“Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone”,研究了靶向利钠肽受体1(natriuretic peptide receptor 1, NPR1)在心力衰竭(HF)中的潜在治疗意义。该研究强调了NPR1在调节血压和静脉张力方面的重要性,并介绍了RE...
近日,来自美国纽约州生物技术公司Regeneron Pharmaceuticals的研究团队在Nature杂志上发表了题为“Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone”的研究论文。该研究开发了一种靶向鸟苷酸环化酶受体 NPR1 的单...
[2] YanLing He, et al. Safety and Blood Pressure Lowering Effects of a Novel and Long-Acting Natriuretic Peptide Receptor 1 Agonist in Healthy Participants: A First-in-Human Clinical Study. AHA 2023. Featured Science 3.
[2] YanLing He, et al. Safety and Blood Pressure Lowering Effects of a Novel and Long-Acting Natriuretic Peptide Receptor 1 Agonist in Healthy Participants: A First-in-Human Clinical Study. AHA 2023. Featured Science 3.
The present disclosure provides a novel immunoglobulin protein that binds to the human natriuretic peptide receptor 1 (NPR1) agonist, preferably an anti NPR1 antibody.In certain embodiments, the protein of the present disclosure comprises at least one immunoglobulin variable domain that binds to the ...
Fig. 3: The NPR1 agonist antibody REGN5381 persistently reduces systolic BP inNPR1hu/humice in the absence of diuresis, and acts as a direct vasodilator. a, Administration of a single subcutaneous dose of 1, 5, 25 or 50 mg per kg REGN5381 in normotensiveNPR1hu/humice demonstrated marked...
We describe the development of REGN5381, an investigational monoclonal agonist antibody thattargets the membrane-bound guanylate cyclase receptor NPR1. REGN5381, an allosteric agonist of NPR1, induces an active-like receptor conformation thatresults in haemodynamic effects preferentially on venous ...
Application of an SA agonist induces the senescence/cell death phenotype in SA-deficient atg mutants but not in atg npr1 plants, suggesting that the cell death phenotypes in the atg mutants are dependent on the SA signal transducer NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1. We also show that ...
2024年9月11日 ,再生元制药公司Michael E. Dunn通讯在《Nature》发表论文“Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone”,研究了靶向利钠肽受体1(natriuretic peptide receptor 1, NPR1)在心力衰竭(HF)中的潜在治疗意义。该研究强调了NPR1在调节血压和静脉张力方面的重要性,并介绍了RE...