Results. Compared with the TT genotype at the NLRC4 gene rs385076 locus, the mortality of HLH patients with TC genotype and CC genotype was higher ( RR = 3.205 , 95% CI: 1.277-4.788, p = 0.012 ; RR = 3.052 , 95% CI: 1.098-4.753, p = 0.031 ). Taking the CC genotype at rs...
[8] Jeskey J, Parida A, Graven K, et al. Novel gene deletion in NLRC4 expanding the familial cold inflammatory syndrome phenotype[J]. Allergy Rhinol (Providence), 2020,11:2152656720928062. DOI: 10.1177/2152656720928062....
(-20℃) 相关类别: 抗原 概述: Fusion protein corresponding to a region derived from 501-700 amino acids of human NLRC4 技术规格: Full name: Synonyms: Swissprot: Gene Accession: Purity: Expression system: Tags: Background: NLR family CARD domain containing 4 CLAN; IPAF; AIFEC; CLAN1; C...
Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. Applications: ELISA, IHC Name of antibody: NLRC4 Immunogen: Fusion protein of human NLRC4 Full name: NLR family CARD domain containing 4 Synonyms: CLAN; IPAF...
reporter. The binding of IL-1β to its receptor on the surface of HEK-Blue™ IL-1β cells triggers a signaling cascade leading to NF-κB/AP-1 activation and subsequent production of SEAP. Levels of SEAP can be easily monitored usingQUANTI-Blue™ Solution. Importantly, the gene encoding...
pneumophila deficient for the flagellin gene flaA b... A Amer,L Franchi,TD Kanneganti,... - 《Journal of Biological Chemistry》 被引量: 969发表: 2006年 TLR5 or NLRC4 is necessary and sufficient for promotion of hum...
Genetic system for cell-specific inflammasome activation To address the physiological consequences of chronic cell type specific NAIP/NLRC4 activation in vivo, we generated a genetically targeted ‘iOvaFla’ mouse that expresses, under Cre-inducible control, a gene encoding chicken ovalbumin (Ova) (...
The overall aim of this project was to determine the molecular mechanisms by which the flagellin gene from Salmonella enterica serovar Typhimurium (S. Typhimurium) activates the NAIP/NLRC4 inflammasome and its contribution to the host protective immune response against salmonellosis.Inflammasomes are mul...
IkappaBzeta controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene. Cytokine 127, 154983. https://doi.org/10.1016/j.cyto.2019.154983 (2020). Article CAS PubMed Google Scholar Ahn, H. et al. Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activa...
Hawn TR, Smith KD, Aderem A, Skerrett SJ: Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila. J Infect Dis. 2006, 193 (12): 1693-1702. 10.1086/504525. Article CAS PubMed Google Schol...