由此,本研究报告了使用AAV血清型8载体(GNT0003)进行基因治疗的多中心、开放标签、I/II期研究的剂量递增部分的安全性和有效性数据。 近期,来自意大利贝加莫最大的公立医院教皇若望23世医院(Papa Giovanni XXIII Hospital)的Lorenzo D’Antiga博士团队领衔...
A 58-year-old Japanese man was admitted to our hospital with appendicitis and marked unconjugated hyperbilirubinemia (11.6 mg/dl). The jaundice worsened following appendectomy, and the directreacting bilirubin increased, probably due to the ceftizoxime administered postoperatively. Bilirubin diglucuronide ...
近期，来自意大利贝加莫最大的公立医院教皇若望23世医院（Papa Giovanni XXIII Hospital）的Lorenzo D’Antiga博士团队领衔在 The New England Journal of Medicine 杂志上发表文章Gene Therapy in Patients with the Crigler-Najjar Syndrome。这项小型临床研究表明，接受载体GNT0003基因治疗的患者没有报告严重不良事件。并且...
症候群 ▾ 外部资源(未审查的) At 0800 hours, an armed terrorist group abducted the civilian Shadi IlyasNajjar,thedriver of a shared taxi, after he had transported some [...] daccess-ods.un.org daccess-ods.un.org 他是一名拼车出 租车司机,在送走来自 Muhradah 地区 Jubbayn 村的几名女教...
【关键词】Crigler—Najjar综合征;新生儿黄疸;尿苷二磷酸葡萄糖醛酸转移酶;突变;家系GeneticanalysisofUGT1A1geneinacaseandherfamilymemberswithCrigler-NajjarsyndrometypeIFengYuling,CaoZongyan.LiuYi,ZhongDanni.DepartmentofPediatrics,theFstAffiliatedHospitalofGuangxiMedi—calUniversity,Nanning530021,ChinaCo~espondingauthor...
Methods Pathological data of 7 036 patients admitted to our hospital since 2000 were reviewed,and clinical manifestations and laboratory findings of 155 patients with hereditary disorders of bilirubin metabolism were compared and analyzed statistically,including 115 cases of Gilbert s syndrome,33 cases of...
著录项 作者单位 Department of Medical Genetics Capital Institute of Pediatrics Beijing 100020 China; Department of Gastroenterology Affiliated Children’s Hospital Capital Institute of Pediatrics Beijing 100020 China;
Ⅱ型Crigler-Najjar综合征1例报告 伍玉南
分析Ｇｉｌｂｅｒｔ综合征（ＧＳ）与Ｃｒｉｇｌｅｒ－Ｎａｊｊａｒ综合征Ⅱ型（ＣＮ－２）患者ＵＧＴ１Ａ１基因突变位点、单倍型及双倍型的差异。方法 回顾性分析２０１０年１月１日—２０１９年１２月３１日就诊于首都医科大学附属北京佑安医院的１３８例ＧＳ与ＣＮ－２患者临床资料，其中ＧＳ组１０９例，ＣＮ...
关键词: Gilbert 综合征;Crigler-Najjar 综合征; UGT1A1 ;基因多态性ResearchprogressofUGT1A1geneinthepathogenesisofGilbertandCrigler-NajjarsyndromesCHEFang,LUOZi-yi(Department of Digestive Disease,the Third Peoples HospitalAffiliated to of Guangdong Medical College,Shenzhen518020,China)Abstract:Gilbertsyndrome(...