基因多态性大肠癌易感性Objective To explore the correlation of MTHFD1 gene polymorphism with genetic susceptibility to colorec-tal cancer. Methods Ninety-six cases of colorectal cancer patients and 96 cases of healthy controls were investigated by questionnaire, the polymerase chain reaction - ...
[Abstract] Objective To explore the correlation of MTHFD1 gene polymorphism with genetic susceptibility to colorectal cancer. Methods Ninety-six cases of colorectal cancer patients and 96 cases of healthy controls were investigated by questionnaire,the polymerase chain reaction - restriction fragment length...
【关键词】亚甲基四氢叶酸脱氢酶1基因;单核苷酸多态性;非综合征性唇腭裂Associationbetweenrs2236225polymorphisminMTHFD1geneandnon-syndromiccleftlipthorwith-outcleftpalateinShanxipopulationZHAOYanbo,Xinhua,NANXinrong.1.030001Taiyuan,DepartmentofStomatology,ShanxiMedicalUni—versityFirstHospital,China;2.Departmentof...
提供的MTHFD1L单克隆抗体(M01), 克隆号1E8产品为小鼠源单克隆抗体,对应的抗体亚型为IgG2a Kappa。该基因又称DKFZp586G1517、FLJ21145、FTHFSDC1、MTC1THFS、dJ292B18.2,全名为methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like。对应Gene号为NM_015440,其蛋白编号为NP_056255。
该MTHFD1 Polyclonal Antibody. This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions...
Inhibition of either BRD4 or MTHFD1 results in similar changes in nuclear metabolite composition and gene expression; pharmacological inhibitors of the two pathways synergize to impair cancer cell viability in vitro and in vivo. Our finding that MTHFD1 and other metabolic enzymes are chromatin ...
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1...
Polymorphisms in MTHFD1 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low Folate Levels 123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778ABBBCCCCCCDDDDDDEEEEEFFFFGG ,...
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1...
We have shown that the common rs2236225 polymorphism in the MTHFD1 gene is an important modulator of CHD risk, especially under conditions of folate deficiency. The results of similar studies have been ambiguous, probably due to the small sample sizes and complex nature of the MTHFD1 metabolic...