Langerhans cells: ▪ are smaller than epithelial cells ▪ have a limitedperikaryon ▪ have numerous long, thin processes ▪ are generally found on or close to thebasement membrane(Fig. 3.1b) ▪ are present at birth throughout the layer and reduce in number away from thelimbusso that...
Islets of Langerhansare composed of four cell types: β cells, which produce insulin;α cells, which produceglucagon;δ cells, which producessomatostatinand thePP cells, which producepancreatic polypeptide. In the mouse, the pancreas first appears as an evagination on the dorsalsurfaceof the primi...
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin+ DC...
One explanation is that Merkel cells may support Langerhans cells that migrate into the basal layer of the bulge and then settle into this microenvironment. These mature or immature Langerhans cells, which are inhibited from circulating from the bulge to other regions, including lymph nodes and ...
Epidermal Langerhans cells (LC) are Birbeck granule-containing bone-marrow-derived cells, which are located mainly in the suprabasal layer of the epidermis... MBM Teunissen - 《Histochemical Journal》 被引量: 153发表: 1992年 Mechanisms in Allergic Contact Dermatitis These molecules, in humans encod...
cells which are mostly located at the basal cell layer of the epidermis (Fig.1). Therefore, we hypothesized that Langerhans cells serve as a reservoir for MCPyV and demonstrated this phenomenon by showing the presence of MCPyV-DNA sequences in microdissected Langerhans cells from dermatopathic ...
a punch biopsy specimen revealed dense aggregates of large epithelioid cells with abundant cytoplasm and reniform nuclei filling the papillary dermis (figure 2). similar-appearing cells were also scattered throughout the epidermis and reticular dermis. immunohistochemical staining of these mononuclear cells...
Cells are color-labeled by cell states (left) and inferred pseudotime (right). Note the bifurcation of progenitor into pre-LC1 and pre-LC2, then into adjacent LC1 and LC2 subsets. (E) Wave-like dynamics of the five co-expressed gene sets across the entire differentiation trajectory. Top, ...
In the area where only basal cells differentiated into flatter epithelium, without a cornified layer, LCs with BGs could also be found. These findings suggest that LCs which originate in bone marrow mature in squamous epithelium. The distribution and morphology of LCs are dependent on the state ...