Treatment of endemic goiter can be carried out by oral administration ofL-thyroxine (100 to 200 mcg/day) for a prolonged period. This putative suppressive therapy induces, through a decrease in TSH and the TSH response to TRH, functional atrophy of the goiter. Results are often satisfactory in...
Twenty-one patients with goiters-four diffuse and 17 nodular-were treated with I-triiodothyronine and I-thyroxine in doses to tolerance. The four diffuse goiters were barely palpable at the end of the treatment. The average dose of I-triiodothyronine required was 100 mcg. per day. The average...