While randomized controlled trials are greatly needed, novel anti﹑ruritic immunomodulatory drugs targeting specific interleukin receptors (IL/13/31) and intracellular signaling (e.g., Janus kinase) pathways may have a potential role in the treatment of this disease....
andabnormalkeratinizationofalltheepidermallay—orsincludingbasalcellsatoneOrmorefocibeneaththeplug.ThediagnosisofKyrle’Sdiseasewasmade.Shewasgivensymptomatictreatmentandthelesionsgotbetter.【Keyword]Kyrle’Sdisease【JClinDemlatol,2007,36(2):96—97】Kyrle病又称真皮穿通性毛囊和毛囊旁角化过度症, 由K yrle于...
First described by Kyrle in 1916, Kyrle disease is a perforating skin condition characterized by the presence of large keratotic papules distributed widely throughout the body. The papules contain a central keratotic plug, which histologically correlates with keratin and necrotic debris. The disease ...
The papules, nodules, and plaques of Kyrle disease tend to occur primarily on the legs, but also develop on the arms and in the head and neck region. Involvement of palms and soles is rare. Ocular changes, including keratotic lesions of conjunctiva and cornea, have been described in a ...
KyrlesdiseaseminocyclinetacalcitolKyrle's disease is a rare perforative skin dermatosis. It was first described in 1916 by J. Kyrle, under the name of hyperkeratosis follicularis et parafollicular in cutem penetrans. It refers to a disorder of keratinization, which usually appears as scattered or...
A fifty-nine year old man is reported herein with a hyperkeratotic papular eruption that clinically and histologically was compatible with Kyrle's disease (hyperkeratosis follicularis et parafollicularis in cutem penetrans). Treatment with tretinoin (topical vitamine A acid) r...
Kyrle's disease is a chronic dermatosis. There is no reliable treatment, local and systemic vitamin-A derivatives are recommended. A case of a 79-year-old patient with a disseminated, plaque-like form of Kyrle's disease is demonstrated below.C. Peter...
Successful treatment of Kyrle disease was achieved with topically applied tretinoin. Its effectiveness appears to depend on its ability to increase epidermal proliferation and to impair keratinization. Because of the beneficial results achieved, a hypothesis that keratinizati...
Kyrle disease (KD), on the other hand, is a rare disorder of keratinization classified among the perforating dermatoses and is associated with diabetes mellitus (DM), hepatic abnormalities and congestive heart failure. We present a case of uremic pruritus and KD in a 64-year-old Chinese man...
This successful antibiotic treatment is to support the role of infectious agents (anaerobic bacteria) in the pathogenesis of Kyrle's disease.doi:10.1016/j.jinf.2007.07.023M. KhalifaI. SlimN. KaabiaF. BahriA. TrabelsiA. Omezzine Letaief