KSHV K8.1, gB, and gH/gL were recently tested as components of a virus-like particle-based candidate vaccine85,86,87. This resulted in KSHV-neutralizing antibodies in immunized mice and rabbits that prevented in vitro infection of epithelial, endothelial fibroblast, and B cells. This suggests ...
先前报道了来自簇3和簇5的许多蛋白的表达取决于病毒DNA聚合酶活性并表现出后期表达动力学,这些蛋白主要是KSHV病毒体的结构成分,例如衣壳蛋白ORF17,ORF25,ORF26,ORF62和ORF65;包膜糖蛋白gB(ORF8),gH(ORF22),ORF39(gM),K8.1和ORF28;以及已知或预测的外皮蛋白ORF75,ORF64,ORF52和ORF42。除结构蛋白外,第5组...
Known copy numbers of serially diluted cosmid GB11 DNA encompassing KSHV genome nt 1-35,022 (U75698) were used as standards in titrating KSHV viral particles. The reaction was conducted and detected by StepOnePlus™ Real-Time PCR system (Applied Biosystems)....
KSHV inhibits expression and function of endothelial cell MHC class II via suppressor of cytokine signalling 3.Butler, L MJeffery, H CWheat, R LLong, H MRae, P CNash, G BBlackbourn, D J
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It was also shown [43] that viral envelop glycoprotein gB can activate the VEGFR-3 receptor and trigger receptor signalling on the surface of microvascular endothelial cells, thereby modulating cell migration and proliferation. VEGFR-3 expression and activation may also enhance HHV-8 infection and ...
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疱疹病毒(herpesvirus)感染极为广泛,几乎每个人都会感染多种疱疹病毒,其感染可引起口唇疱疹、多种癌症、疱疹性脑炎、带状疱疹及多种神经系统疾病等,特别对小儿、孕妇及免疫力低下人群造成极大威胁。不同类型的疱疹病毒具有相似的生命周期——潜伏感染和裂解复制。目前,我们对于疱疹病毒生命周期的调控,特别是宿主因子在其中...
Like gB, K8.1A also facilitates attachment to target cells by binding to heparan [33], but it is not necessary for infection [35]. 3. Host Cellular Binding and Entry Receptors Used by KSHV Like several other viruses, KSHV engages two kinds of receptors to enter cells: binding and entry ...