JNK/MAPK pathwayliver tissuemicroarray datasetoxidative stressBackground Alcoholic hepatitis (AH) is a severe alcoholic‐related liver disease that is a leading cause of morbidity and mortality, for which effective treatments are lacking. Brain‐expressed X‐linked gene 2 (BEX2) has been implicated ...
人们普遍认为JNK是肝脏中的促凋亡蛋白,JNK/MAPK信号通路被证实是H2S的靶标。研究表明,外源性H2S补充可以通过减轻MAPK信号通路来改善氧化应激诱导的成骨细胞损伤;外源性H2S补充减轻了铀诱导的急性肝毒性和铀激活的JNK磷酸化状态。 在本研究中...
JNK又被称为应激活化蛋白激酶,是哺乳类细胞中MAPK(丝裂原活化蛋白激酶)信号通路的另一亚类。JNK蛋白激酶由3个基因编码,JNK1和JNK2基因在全身广泛表达,而JNK3基因主要在脑中表达,在心脏和睾丸中表达较少【4】。JNK1/2参与免疫细胞的...
2 0 0 9中华中医药2377学刊p38/JNK MAPK 信号通路在 Th 细胞分化中的作用陈晋广 1 ,朱明芳 2(1. 台州市立医院皮肤科,浙江 台州 318000;2. 湖南中医药大学第二附属医院皮肤科,湖南 长沙 410005)摘要:p38/JNK MAPK 信号转导通路与多种肿瘤或增殖性疾病关系密切,是一条关键的调节细胞增生和凋亡的通路,是...
JNK又被称为应激活化蛋白激酶,是哺乳类细胞中MAPK(丝裂原活化蛋白激酶)信号通路的另一亚类。JNK蛋白激酶由3个基因编码,JNK1和JNK2基因在全身广泛表达,而JNK3基因主要在脑中表达,在心脏和睾丸中表达较少【4】。JNK1/2参与免疫细胞的调节和胚胎神经系统的发育,而JNK3是应激刺激激活的主要亚型,主要参与神经变性过程...
A role for some MAPKs (e.g., extracellular signal-regulated kinase, Erk1/2) has been documented in response to certain physiological stimuli, such as ischemia, visceral pain and electroconvulsive shock. We recently demonstrated that restraint stress activates the Erk MAPK pathway, but not c-Jun...
‘d1 V01.1 5 Engineenng Ap^I9.2009 3,N0.1 炙7乏震基础医学 MAPK信号转导通路中ERK、JNK和P38在大鼠肝脏缺血再灌注和 缺血后处理中表达的变化 周正’,朱云祥1,李强1,叶启发2,牛英2 of P38inMAPK transduction ChangesERK,JNK,and signaI pathwayfo¨owinghepatiC andischemic inrats postconditioning ...
结论: 波动性高血糖较稳定性高血糖更促进糖尿病肝细胞的凋亡,其机制与JNKMAPK 信号转导通路激活有关。[关键词] 肝细胞; 血糖波动; 氧化应激; JNKMAPK 信号通路 [中图分类号] R587畅1;R363 [文献标志码] Adoi:10.3969/j.issn.10004718.2015.07.019OxidativestressactivatedJNKMAPKsignalingpathwayisinvolvedin...
The expression or activity of JNK and p38 MAPK pathway components is often altered in human tumours and cancer cell lines. Given the many tumorigenesis-related functions that these kinases can control, both in the cancer cell and in the tumour microenvironment, it is important to carefully conside...
人类疾病的发生与发展中起着至关重要的作用,因 1.2.2信号通路的细胞内激活物JNK 典型的促 此JNK信号通路是正常与疾病状态时细胞的一个重 分裂原活化的蛋白激酶(MAPK)信号通路包括3个连 要调节靶点。 续的酶促反应,即MAPKKKs→MAPKKs→MAPKs。 1.1 及其编码基因JNK JNKs的直接上游激酶MAPKKs目前确认的只有 ...