The expression patterns of JHDM1D-AS1, miR-940 and ARTN in BC cells were altered by lentivirus infection and plasmid transfection for functional assays on the biological properties of BC cells. Finally, the tumorigenic and metastatic abilities of BC cells were assessed in vivo.ResultsJHDM1D-AS1 ...
结果 H2O2诱导的PC12细胞中JHDM1D-AS1表达水平明显降低,miR-144-3p表达水平明显升高(P<0.05)。过表达JHDM1D-AS1后,H2O2诱导的PC12细胞中JHDM1D-AS1表达水平明显升高,miR-144-3p表达水平明显降低,细胞凋亡率降低,SOD活性明显升高,MDA含量明显降低,TNF-α、IL-1β含量明显降低(P<0.05)。JHDM1D-AS1靶向调控miR-...
JHDM1D antisense 1 (JHDM1D-AS1), a long non-coding RNA (lncRNA), has been shown to promote pancreatic cancer growth by inducing an angiogenic response. However, its biological and clinical significance in non-small-cell lung cancer (NSCLC) is still unclear. In this study, we examined the...
Functionally, JHDM1D-AS1 depletion caused an obvious reduction in cell proliferation and invasion both in vitro and in vivo, while the addition of miR-450a-2-3p inhibitor could nullify these effects. Mechanically, JHDM1D-AS1 promoted GC progression via the sponging of miR-450a-2-3p in order...
JHDM1D-AS1miR-450a-2-3pPRAF2Gastric cancerAims: To investigate the molecular function and mechanisms of JHDM1D antisense 1 (JHDM1D-AS1) during gastric cancer (GC) progression.Wu, MinLiu, YiPu, Yan-SongMa, YuWang, Jian-HuaLiu, En-Qi...
JHDM1D-AS1 expression was decreased by MPP+in SK-N-SH cells in a dose- or time-dependent manner. Functionally, JHDM1D-AS1 overexpression attenuated MPP+-evoked neuronal apoptosis, inflammation, and oxidative stress. Mechanistically, JHDM1D-AS1 competitively bound to miR-134-5p to upregulate the ...
JHDM1D-AS1miR-101-3pDUSP1Brachial plexus injuryNeuroinflammationBackground: Neuroinflammation in the spinal cord following acute brachial plexus injury (BPI) remains a vital cause that leads to motor dysfunction and neuropathic pain. In this study, we aim to explore the role of long non-coding ...
JHDM1D-AS1PDLSCDNAJC10ApoptosisPeriodontal ligament stem cells (PDLSCs) are a promising tool for regenerative medicine in clinical periodontal ligament repair. However, clinical maintenance of high quality and large quantity of PDLSCs faces multiple obstacles. One of them is how PDLSCs respond to ...