In this work, we have used ab initiocalculations,continuum solvation models, and intrinsic reaction coordinate methodto support the WAIA mechanism for normal ester. In thecase of activated esters, the process can also be viewed as waterautoionization with formation of hydroxide ion aided by a ...
Herbert J B M,Blumenthal E.Mechanism of hydrolysis of inor-ganic esters. Nature . 1939Herbert J B M, Blumenthal E. Mechanism of hydrolysis of inorganic esters[J]. Nature, 1939, 144: 248-248.Herbert J B M,Blumenthal E. Mechanism of hydrolysis of inorganic esters[J].Nature 1939,144....
It was shown 1,2 that alkyl esters of the 2′- and 3′-monoribonucleotides (partial formula I ; R = alkyl) provided simple model substances which could be used for a more precise study of the mechanism of hydrolysis. The overall process, effected by acid or by alkali, results in a ...
Transition state differences in hydrolysis reactions of alkyl versus aryl phosphate monoester monoanions. Although aryl phosphates have been the subject of numerous experimental studies, far less data bearing on the mechanism and transition states for alkyl pho... PK Grzyska,PG Czyryca,J Purcell,....
While for the compound of N-(isopropylcarbamoyl-methoxyphosphony1)-卤-amino acid ester (11). only the P-O bond cleaves. The possible mechanism is discussed.doi:10.1080/10426509608043485Hui-Ying LiRu-Yu ChenKang-Tai RenTaylor And FrancisPhosphorus Sulfur and Silicon and the Related Elements...
Catalysis of p-nitrophenyl butyl chloromethylphosphonate hydrolysis by higher amines Solutions of partly protonated higher primary amines (≥C 6 ) contain mixed micelles that catalyze the hydrolysis of the ester bonds at the phosphorus through the general basic mechanism. The catalytic rate constants in...
Cycloadditions of two thiocarbonyl ylides with α,β-unsaturated esters and nitriles: steric course and mechanism1,3-dipolar cycloadditions... R Huisgen,G Mloston,H Giera,... - 《Tetrahedron》 被引量: 71发表: 2002年 The One-Pot Wittig Reaction: A Facile Synthesis of ,β-Unsaturated Este...
22、The mechanism involves a combination ofhydrolysisof the ester linkages and enzymatic attack on ether and amide bonds.(该机制涉及的联系和对醚酯和酰胺键水解酶的攻击组合。) 23、Thehydrolysisof peanut meal using neutral protease was investigated.(选用中性蛋白酶对花生粕进行单酶水解研究。) ...
The preparation and alkaline hydrolysis of 18O-methyl 2,2-dimethylpropanoate and 18O-methyl triphenylacetate are reported. From mass spectral analysis of the carboxylic acid products, it is concluded that the former substrate is hydrolyzed exclusively by the BAC2 mechanism, whereas the latter ...
ofcarboxylicacidderivativessuchasamideshasbeenstudiedmoreoften2−4duetotheirrelationwiththepeptidebondcleavageinproteins.Inthecaseoflactonehydrolysis,thedisproportionisevenlarger,computationalworksbeingespeciallyscarce.Theexistingmechanismsofacid-catalyzedesterhydrolysiscanbeseenasthecounterpartsofthoseofneutralhydrolysis,...