High Grade Glioma: Glioblastoma (GBM)Also known as: Glioblastoma / Glioblastomas / Glioblastoma (GBM) / Glioblastomas (GBM) / GBM / Glioblastoma (morphologic abnormality) / Glioblastoma multiforme / Glioblastoma multiforme (disorder) Drugs Drugs and Targets Drug Trials DrugDrug NameDrug Description ...
GLIADEL® Wafer is indicated for the treatment of patients with newly-diagnosed high-grade glioma as an adjunct to surgery and radiation and for patients with recurrent glioblastoma as an adjunct to surgery.
Varun Monga, MD, discusses the investigation of the protein arginine methyltransferase 5 brain-penetrant inhibitor PRT811 in patients with recurrent high-grade glioma or uveal melanoma.
Stereotactic radiosurgery and hypofractionated radiotherapy for glioblastoma. Neurosurgery. 2018;82(1):24–34. https://doi.org/10.1093/neuros/nyx115. Article Google Scholar Kong L, Wu JS, Gao J, Qiu XX, Yang J, Hu J, et al. Particle radiation therapy in the management of malignant glioma...
SOX2 is pervasively expressed in high-grade glioma cells There is currently no universal marker that can consistently and specifically label transformed cells across HGGs. While it is unlikely that such a marker exists, we sought to determine whether our scRNA-Seq profiles could reveal genes that...
diagnosis of progression of disease in MRI for all patients.#20 multifocal glioma cases (18 IDH wild-type glioblastoma cases, one diffuse astrocytic glioma, IDH wild-type case with molecular features of glioblastoma and one anaplastic astrocytoma, IDH wild-type case) were included into the ...
Chimeric antigen receptor T cell (CAR-T) therapy is an emerging strategy to improve treatment outcomes for recurrent high-grade glioma, a cancer that responds poorly to current therapies. Here we report a completed phase I trial evaluating IL-13Rα2-targ
GBglioblastoma GFAPglial fibrillary acidic protein GKSgamma knife surgery HEhematoxylin and eosin GTRgross total resection HGGhigh-grade glioma IDHisocitrate dehydrogenase K(ep)mean rate transfer coefficient LAT1L1 amino acid transporter LElevel of evidence according tohttps://guides.library.stonybrook.edu...
Patients with recurrent high-grade glioma (rHGG), such as glioblastoma, face a dismal prognosis with median overall survival rates of less than 1 year1,2. This is likely related to the biological nature of these types of tumors which are characterized as fast growing, infiltrating, and frequen...
"Conventional therapy options for patients with high-grade glioma, including glioblastoma, are limited and innovation in the field has too long been stagnant, leaving patients with poor outcomes and significant tradeoffs in quality of life. By non-invasively targeting and eradicating tumor through the...