(IL-2), while TH2 cells mainly synthesize theinterleukinsIL-4, IL-5, IL-6, IL-9, IL-10, and IL-13. The main role of the TH1 cells is to stimulate cell-mediated responses (those involving cytotoxic T cells and macrophages), while TH2 cells primarily assist in stimulating B cells ...
辅助性T[淋巴]细胞; 英英释义 helper T cell n.T cell with CD4 receptor that recognizes antigens on the surface of a virus-infected cell and secretes lymphokines that stimulate B cells and killer T cells; helper T cells are infected and killed by the AIDS virus ...
T-cells are considered to have a crucial role in the regulation of antibody and other immune responses. Some T-cells,helper cells, augment theantibody responseof B-cells. Other T-cells, suppressor cells, diminish the antibody response. Both these phenomena are complex, involving multiple cellular...
Differentiation of periperal T cells into TH1 and TH2 subsets is a crucial part of a normal immune response. Evidence is emerging that a signaling pathway involving the SAP molecule may play an important role in this differentiation process....
University of Melbourne’s Emma Bawden, PhD, a postdoctoral researcher at the Doherty Institute and lead author of the study, said this discovery challenges the conventional understanding of the role of CD4+ T cells in cancer immunity. For decades, CD4+ T cells have been considered as a suppor...
Cytotoxic T lymphocytes (CTLs) are efficient in keeping the viral replication under control during acute phase of infection but lose their protective function during later stages under the suppressive effect of Regulatory T cells. As a result of this, the virus manage to escape immune surveillance...
1–4 In a rat model wherein myocarditis is inducible by purified cardiac myosin, T cells reportedly play an important role in inducing myocarditis. 5,6 This model may serve as a system to investi- gate the pathological mechanisms underlying postinfectious myocardial injury by autoimmunity. It ...
Helper T-cells are immune cells that can be thought of as the captains of the adaptive immune system. This is because they release signals that direct and coordinate the activities of the immune system. Answer and Explanation:1 IgE does not activate helper T-cells. IgE is a type of antibod...
CD4+ T helper cells are key regulators of host health and disease. In the original model, specialized subsets of T helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs, but recent studies have
Although T cells are one of the major sources of GM-CSF, the phenotype of the GM-CSF-producing T cells has not been determined.29,30 It has been shown that most T cells lose the ability to synthesize GM-CSF during differentiation,31 but the exact role of either Th1 or Th2 cytokines,...