加拿大渥太华大学研究人员 Maryam Moini 和多伦多大学研究人员 Scott Fung 近日发表了综述性文章:HBsAg 阴转作为功能性治愈重要治疗终点(HBsAg Loss as a Treatment Endpoint for Chronic HBV Infection: HBV Cure),文章很好地概述了正目前在开发的用于治疗慢性乙型肝炎的不同化合物。然而,根据最近几个月来在该...
但需要强调的是HBsAg clearance 不等于 HBV functional cure,珠峰项目并未提供停药后的随访数据。 2 核苷酸类药物 近几年的研究显示,长期使用核苷酸类药品的病人停药后,在不出现Hepatitis flares的人群中PD-1阳性的HBV-specific T细胞显著增加。作为对照HBV慢性感染病人的血液得的ex vivo实验中无法发现HBV-specific T细...
参考文献: 1. Lin CL, et al. Review article: novel therapies for hepatitis B virus cure - advances and perspectives. Aliment Pharmacol Ther. 2016 Aug;44(3):213-22. 2. Zoulim F, et al. Current treatments for chronic hepatitis B virus infections. Curr Opin Virol. 2016 Jun 15;18:109-11...
Fung S, Choi HSJ, Gehring A, Janssen HLA. Getting to HBV cure: the promising paths forward. Hepatology. 2022;10.1002/hep.32314. doi:10.1002/hep.32314.
HBV cure-can we pin our hopes on immunotherapy? Nat. Rev. Gastroenterol. Hepatol. 2015; 12 :129–131. doi: 10.1038/nrgastro.2015.8. [ Cross Ref ]Yang HC, Kao JH. Viral hepatitis. HBV cure-- can we pin our hopes on immunotherapy? Nat Rev Gastroenterol Hepatol 2015; 12: 129-131 [...
[1] Tarik Asselah, Dimitri Loureiro, Nathalie Boyer, Abdellah Mansouri. Targets and future direct-acting antiviral approaches to achieve hepatitis B virus cure. Lancet Gastroenterol Hepatol (2019); 4: 883–892. [2] Gregory C. Fanning, Fabien Zoulim,...
1. Immunomodulatory and Antiviral Therapy Improved Functional Cure Rate in CHB Patients with High HBsAg Level Experienced NA.Journal of Clinical and Translational Hepatology 2023 vol. 11(5) 2. Seroclearance of HBsAg in Chronic Hepatitis B Patients after a Tolerance-Breaking Therapy: GM-CSF, followed...
点击文末“阅读原文/Read more”,即可 访问Gastroenterology 官网阅读完整论文。 参考资料 [1] Yardeni D, et al., (2022). Current Best Practice in Hepatitis B Management and Understanding Long-term Prospects for Cure. Gastroenterology, doi: 10.1053/j.gastro.2022.10.008....
慢性HBV感染免疫耐受期患者自发地出现免疫清除后大部分患者进入免疫控制期[1],此期患者血清抗-HBe阳性,HBV DNA通常检测不到或处于低水平(<2000 IU/ml),血清HBsAg一般为低水平(<1000 IU/ml),并伴有持续正常的ALT和轻度肝脏炎症坏死及纤维化。目前国内外对免疫控制...
文献来源: Meng Z, Chen Y, Lu M. Advances in Targeting the Innate and Adaptive Immune Systems to Cure Chronic Hepatitis B Virus Infection. Front Immunol. 2020;10:3127. Published 2020 Feb 7. doi:10.3389/fimmu.2019.03127 版 权 声 明